There are a lot of possible complications after extraction of a lower third molar. They occur because of its specific position from which an infection can spread. Alveotomy is a surgical removal of a tooth that implies a targeted removal of bone which prevents the tooth from growing and therefore makes its extraction possible. Most common indications for alveotomy are impacted and retained tooth. During a preoperative mostly evaluation it is important to take detailed amnesias, make an clinical examination and x-ray of the area in question. After a finished procedure a patients has to be given postoperative instructions. Postoperative complications are mostly related to wound healing which may be normal or an alveolar osteitis can be developed. Further complications after a tooth extraction include bleeding, postoperative edema, trimus, infection, pain, temporomandibular disorder and mandibular fractures. Literature is filled with numerous method for infection control after extraction of a lower wisdom tooth. They include various methods for a wound closure with or without drainage, use of analgesic, corticosteroids and antibiotic. Profilactic use is based on preoperative ordination of antibiotics with the purpose of prevention of bacterial infection. Other methods like: criotherapy, usage of lasers, ozone, PRGF and PRF, are also used in control of postoperative complications. PRGF tehnology is a turning point in stimulation and regeneration of different tissues. PRGF is an autologous device and it enables an interaction with various biomaterials in a great deal of pathological cases. PRGF-Endoret usage reduces inflammation, pain and speeds up the process of epitalisation of soft tissue and increases bone regeneration. PRF is a biomaterial which is in wide use in oral surgery because he enables and increases the regeneration of soft, hard and bone tissue.