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master's thesis
Koštana regeneracija u oralnoj kirurgiji
Zagreb: University of Zagreb, School of Dental Medicine, 2017. urn:nbn:hr:127:971207
Fatović, Antonia
University of Zagreb
School of Dental Medicine
Department of Oral Surgery

Institutional repository: University of Zagreb School of Dental Medicine Repository

Cite this document

Fatović, A. (2017). Koštana regeneracija u oralnoj kirurgiji (Master's thesis). Zagreb: University of Zagreb, School of Dental Medicine. Retrieved from https://urn.nsk.hr/urn:nbn:hr:127:971207

Fatović, Antonia. "Koštana regeneracija u oralnoj kirurgiji." Master's thesis, University of Zagreb, School of Dental Medicine, 2017. https://urn.nsk.hr/urn:nbn:hr:127:971207

Fatović, Antonia. "Koštana regeneracija u oralnoj kirurgiji." Master's thesis, University of Zagreb, School of Dental Medicine, 2017. https://urn.nsk.hr/urn:nbn:hr:127:971207

Fatović, A. (2017). 'Koštana regeneracija u oralnoj kirurgiji', Master's thesis, University of Zagreb, School of Dental Medicine, accessed 28 December 2024, https://urn.nsk.hr/urn:nbn:hr:127:971207

Fatović A. Koštana regeneracija u oralnoj kirurgiji [Master's thesis]. Zagreb: University of Zagreb, School of Dental Medicine; 2017 [cited 2024 December 28] Available at: https://urn.nsk.hr/urn:nbn:hr:127:971207

A. Fatović, "Koštana regeneracija u oralnoj kirurgiji", Master's thesis, University of Zagreb, School of Dental Medicine, Zagreb, 2017. Available at: https://urn.nsk.hr/urn:nbn:hr:127:971207

Metadata
TitleKoštana regeneracija u oralnoj kirurgiji
Title (english)Bone regeneration in oral surgery
AuthorAntonia Fatović
MentorAna Kotarac Knežević (mentor)
Committee memberAna Kotarac Knežević (predsjednik povjerenstva)
Committee memberTomislav Škrinjarić (član povjerenstva)
Committee memberMarko Granić (član povjerenstva)
GranterUniversity of Zagreb
School of Dental Medicine
(Department of Oral Surgery)
Zagreb
Defense date and country2017-09-27, Croatia
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Dental Medicine
Oral Surgery
Abstract
Kost posjeduje iznimnu regenerativnu sposobnost pa većina ozljeda cijeli bez nastanka ožiljkastog tkva. Međutim, različiti lokalni i sitemski uzroci mogu kompromitirati koštano cijeljenje i kao rezultat imati nastanak koštanih defekata. U takvim situacijama kirurškim metodama može se potaknuti koštana regeneracija. Autogena i alogena kost, ksenogeni transplantati i aloplastični materijali samostalno ili u kombinaciji s membranama u tehnici vođene regeneracije kosti (engl. guided bone regeneration, GBR) materijali su koji se dugo godina koriste za obnovu koštanog tkiva. Trombocitima obogaćena plazma (engl. platelet rich plasma, PRP), trombocitima obogaćen fibrin (engl. platelet rich fibrin, PRF) i plazma bogata faktorima rasta (engl. plasma rich in growth factors, PRGF) preparati su dobiveni centrifugiranjem krvi pacijenta i predstavljaju optimizirani krvni ugrušak. Upotrebom trombocitnih preparata može se pospješiti proces cijeljenja poticanjem neoangiogeneze, proliferacije fibroblasta, stvaranja kolagena, mitoze mezenhimalnih matičnih stanica i osteoblasta. Dok učinak PRP-a na koštanu regeneraciju još uvijek nije točno definiran, PRGF i PRF nalaze široku primjenu u oralnoj kirurgiji. Od njihovog otkrića 1965. godine, koštani morfogenetski proteini (engl. bone morphogenetic proteins, BMP) privlače pažnju i predmet su brojnih istraživanja. Zbog pleotropne naravi ovih faktora rasta, osim izvrsnih rezultata u poticanju regeneracije koštanih defekta, njihova primjena nosi i određene rizike. Potraga za idealnim nosačem koji bi omogućio primjenu BMP-a u nižim koncentracijama još uvijek traje.
Abstract (english)
Bone possesses exceptional ability for regeneration so most injures heal without scar tissue. However, different local and systemic factors can compromise bone healing and result in bone defects. In those situations, surgical methods are used to promote bone regeneration. Autogenous and allogenic bone, xenografts and alloplastic materials alone or in combination with membranes in guided bone regeneration technique (GBR) have been used for many years to restore bone tissue. Platelet rich plasma (PRP), platelet rich fibrin (PRF) and plasma rich in growth factors (PRGF) are supplements obtained by centrifugation of the patient’s blood, representing an optimized blood clot. The use of platelet concentrates can improve the healing process by stimulating neoangiogenesis, fibroblast proliferation, collagen formation, osteoblast and mesenchymal stem cell mitosis. While the effect of PRF on bone regeneration is still not precisely defined, PRGF and PRP are widely used in oral surgery. Since they were discovered in 1965, bone morphogenetic proteins (BMP) have been attracting a lot of attention and were subjects of numerous studies. Due to their pleotropic nature, besides excellent results in inducing bone defects regeneration, their use carries certain risks. The search for an ideal carrier which would allow the use of BMP at lower concentrations is still ongoing.
Keywords
Keywords (english)
Languagecroatian
URN:NBNurn:nbn:hr:127:971207
Study programmeTitle: dental medicine
Study programme type: university
Study level: integrated undergraduate and graduate
Academic / professional title: doktor/doktorica dentalne medicine (doktor/doktorica dentalne medicine)
Type of resourceText
File originBorn digital
Access conditionsOpen access
Terms of useLicence Attribution-NoDerivatives 4.0 International (CC BY-ND 4.0) icon
Created on2018-01-19 10:40:16