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master's thesis
Antimikrobna fotodinamska terapija u parodontologiji
Zagreb: University of Zagreb, School of Dental Medicine, 2017. urn:nbn:hr:127:238029
Veličan, Sandra
University of Zagreb
School of Dental Medicine
Department of Periodontology

Institutional repository: University of Zagreb School of Dental Medicine Repository

Cite this document

Veličan, S. (2017). Antimikrobna fotodinamska terapija u parodontologiji (Master's thesis). Zagreb: University of Zagreb, School of Dental Medicine. Retrieved from https://urn.nsk.hr/urn:nbn:hr:127:238029

Veličan, Sandra. "Antimikrobna fotodinamska terapija u parodontologiji." Master's thesis, University of Zagreb, School of Dental Medicine, 2017. https://urn.nsk.hr/urn:nbn:hr:127:238029

Veličan, Sandra. "Antimikrobna fotodinamska terapija u parodontologiji." Master's thesis, University of Zagreb, School of Dental Medicine, 2017. https://urn.nsk.hr/urn:nbn:hr:127:238029

Veličan, S. (2017). 'Antimikrobna fotodinamska terapija u parodontologiji', Master's thesis, University of Zagreb, School of Dental Medicine, accessed 26 November 2024, https://urn.nsk.hr/urn:nbn:hr:127:238029

Veličan S. Antimikrobna fotodinamska terapija u parodontologiji [Master's thesis]. Zagreb: University of Zagreb, School of Dental Medicine; 2017 [cited 2024 November 26] Available at: https://urn.nsk.hr/urn:nbn:hr:127:238029

S. Veličan, "Antimikrobna fotodinamska terapija u parodontologiji", Master's thesis, University of Zagreb, School of Dental Medicine, Zagreb, 2017. Available at: https://urn.nsk.hr/urn:nbn:hr:127:238029

Metadata
TitleAntimikrobna fotodinamska terapija u parodontologiji
Title (english)Antimicrobial photodynamic therapy as a therapy in the treatment of periodontitis
AuthorSandra Veličan
MentorDomagoj Vražić (mentor)
Committee memberDomagoj Vražić (predsjednik povjerenstva)
Committee memberIvan Puhar (član povjerenstva)
Committee memberRobert Ćelić (član povjerenstva)
GranterUniversity of Zagreb
School of Dental Medicine
(Department of Periodontology)
Zagreb
Defense date and country2017-09-22, Croatia
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Dental Medicine
Periodontology
Abstract
Mehanička terapija (SRP) parodontnih bolesti nerijetko je potpomognuta antibioticima i antisepticima koji mogu imati štetne posljedice za pacijenta i uzrokovati bakterijsku rezistenciju. Antimikrobna fotodinamska terapija (aPDT) je neinvazivna fotokemoterapija koja ubija bakterije i njihove toksine te predstavlja moguću alternativu antibioticima. Djelovanje aPDT-a se temelji na reakciji fotoaktivatora i izvora svjetla. Aktivirani fotoaktivator se spaja s molekularnim kisikom te nastaje atomarni kisik koji direktno uništava DNA i stijenku mikroorganizama. Zbog izravnog djelovanja, mikroorganizmi na ovakvu vrstu terapije ne mogu razviti rezistenciju. Također, zbog sposobnosti fotoaktivatora da prođe epitelnu barijeru, aPDT može uspješno djelovati na mikroorganizme koji koloniziraju vezivno tkivo. Od kad je, početkom prošlog stoljeća otkriven utjecaj metilenskog modrila i svjetla na smanjenje pokretljivosti papučice, interes za antimikrobno svojstvo fotodinamske terapije se s godinama samo povećavao. Od početnih in vitro istraživanja o samom mehanizmu djelovanja, do današnjih kliničkih studija o mogućnostima liječenja različitih parodontnih stanja i bolesti aPDT-om, proveden je određeni broj istraživanja s različitim rezultatima. Dok se u liječenju kroničnog parodontitisa aPDT iskazao kao obećavajuća pomoćna terapija, rezultati istraživanja o liječenju agresivnog parodontitisa razlikuju se među raznim skupinama autora, no postoji određeni konsenzus oko povoljnog kratkoročnog učinka. S obzirom na kontradiktornost rezultata i relativno mali broj provedenih kliničkih istraživanja, trebalo bi pričekati na rezultate dodatnih istraživanja na većem broju pacijenata.
Abstract (english)
In periodontology, scaling and root planning is often assisted by antibiotics and antiseptics that can cause a number of adverse effects and bacterial resistance. APDT is a non-invasive phototherapy that kills bacteria and their toxins and it is a possible alternative to antibiotics. The action of aPDT is based on the reaction of the photosensitizer and light sources. The activated photosensitizer binds with molecular oxygen producing the “singlet” oxygen that directly destroys the DNA and the wall of microorganisms. Due to its direct action, microorganisms cannot develop resistance to this type of therapy. Also, because of the ability of the photoactivators to pass the epithelial barrier, aPDT can successfully reduce the microorganisms that colonize the connective tissue. Since the discovery of the influence of methylene blue and light on the reduction of pedal mobility, at the beginning of the last century, the interest in aPDT has only increased. From the initial in vitro researches on the mechanism of action, until today’s clinical trials on the possibilities of treating different periodontal conditions and diseases, a number of researches about aPDT with different results were conducted. While aPDT has been shown as promising adjunctive therapy in the treatment of chronic periodontitis, the results of the treatment of aggressive periodontitis are not the same in all studies, but there is a certain consensus about the favorable short-term effect. Given the contradiction of the results, we should wait for more studies on a larger number of patients.
Keywords
Keywords (english)
Languagecroatian
URN:NBNurn:nbn:hr:127:238029
Study programmeTitle: dental medicine
Study programme type: university
Study level: integrated undergraduate and graduate
Academic / professional title: doktor/doktorica dentalne medicine (doktor/doktorica dentalne medicine)
Type of resourceText
File originBorn digital
Access conditionsOpen access
Terms of useLicence Attribution-NoDerivatives 4.0 International (CC BY-ND 4.0) icon
Created on2018-01-19 11:35:53