Occlusion plays an important role both in classic prosthodontics and implant prosthetic therapy. Uneven occlusal relations can lead to biological and technical complications. Biological complications include losing marginal bone around the implant and technical complications include fracture of the implant and losing the integrity of the prosthetic work on implants. To understand specific occlusal principles in implant prosthodontics, it is important to understand the differences between the tooth and the implant. The key difference is the connection with the bone: tooth has the periodontal ligament while the implant is osseointegrated in the bone. Compared with the implant, because of the periodontal ligament, the tooth has much favourable transition of both axial and horizontal occlusal forces on the surrounding bone as well as greater level of mobility and proprioceptors that can protect the tooth form occlusal overload using reflex mechanisms. There is a lack of scientific research regarding the influence of the occlusal overload on the onset of the biological complications and the results are often contrasting. It can be concluded with certainty that occlusal overload leads to quicker bone loss when plaque and inflamation are present in periimplant tissue and to onset of technical complications. Further investigations are recommended. It is important to protect the implant from occlusal overload and non-axial forces that can cause damage by using implant protected occlusion and specific modelling of prosthetic work. Implant protected occlusion is based on mutually protected occlusion with some modifications. Planning of implant therapy should take into consideration the state of the entire stomatognathic system; number of missing teeth, condition of the opposing jaw, presence of the parafunctional activity. Taking into consideration all of the abovementioned factors, occlusal principles in implant prosthetic therapy should be individually planed.