Introduction. The face has a major significance in every aspect of human life. As a major tool of human nonverbal communication it has an impact on our social relations. The psychosocial aspects of dermatological disease usually impact the patient’s general health and can lead to feeling of isolation and loneliness. Physicians have focused on treatments and minimizing side effects. However, a broad spectrum of patient needs are also factors in treatment success. The aim of the study is to examine different predictors of the quality of life in patients with dermatological disease visible on face. Methods. The study included one hundred and eighty two patients with acne vulgaris, rosacea and dermatitis seborrhoica which were treated in an outpatient treatment at the Department of Dermatovenerology, Sestre milosrdnice University Hospital Center in Zagreb. Participants were divided into three groups. In the first group of patients, sixty were those with rosacea. In the second group there were seventy patients with acne vulgaris and in third group fifty-two patients with dermatitis seborrhoica. Consenting participants completed the following standardizes psychological questionnaires: Dermatology Life Quality Index, Personal Wellbeing Index and Perceived Stress Scale. Results. The results of the study showed a significant positive correlation between the clinical assessment of the severity of the disease and the influence of dermatological disease on the quality of life in the group of seborrheic dermatitis patients, whereas in other diseases the difference was not found. Rosacea sufferers achieve significantly lower overall quality of life compared with acne vulgaris sufferers, but no difference in the quality of life between those with rosacea and those suffering from seborrheic dermatitis was found. Acne vulgaris sufferers achieve significantly lower quality of life in areas of material standard, health and safety in the future compared with those suffering from rosacea and seborrheic dermatitis, with no difference. Conclusion. Dermatological quality of life has proved to be a significant predictor of the overall quality of life. High levels of stress have been identified in patients with dermatological diseases, but there is no difference in the level of stress between those with rosacea, acne vulgaris or seborrheic dermatitis. Dermatological quality of life and stress proved to be significant predictors of overall quality of life. Because of its recurrent character, frequent unsatisfying results of treatment and a cosmetic problem, skin lesions can cause negative patients' psychosocial functioning. Quality of life outcomes represent an important approach by which physicians and patients can better assess the effects of treatments.