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master's thesis
Plazma obogaćena trombocitima, fibrin obogaćen trombocitima i plazma bogata faktorima rasta u oralnoj kirurgiji
Zagreb: University of Zagreb, School of Dental Medicine, 2019. urn:nbn:hr:127:509514
Šeba, Mirjana
University of Zagreb
School of Dental Medicine
Department of Oral Surgery

Institutional repository: University of Zagreb School of Dental Medicine Repository

Cite this document

Šeba, M. (2019). Plazma obogaćena trombocitima, fibrin obogaćen trombocitima i plazma bogata faktorima rasta u oralnoj kirurgiji (Master's thesis). Zagreb: University of Zagreb, School of Dental Medicine. Retrieved from https://urn.nsk.hr/urn:nbn:hr:127:509514

Šeba, Mirjana. "Plazma obogaćena trombocitima, fibrin obogaćen trombocitima i plazma bogata faktorima rasta u oralnoj kirurgiji." Master's thesis, University of Zagreb, School of Dental Medicine, 2019. https://urn.nsk.hr/urn:nbn:hr:127:509514

Šeba, Mirjana. "Plazma obogaćena trombocitima, fibrin obogaćen trombocitima i plazma bogata faktorima rasta u oralnoj kirurgiji." Master's thesis, University of Zagreb, School of Dental Medicine, 2019. https://urn.nsk.hr/urn:nbn:hr:127:509514

Šeba, M. (2019). 'Plazma obogaćena trombocitima, fibrin obogaćen trombocitima i plazma bogata faktorima rasta u oralnoj kirurgiji', Master's thesis, University of Zagreb, School of Dental Medicine, accessed 04 November 2024, https://urn.nsk.hr/urn:nbn:hr:127:509514

Šeba M. Plazma obogaćena trombocitima, fibrin obogaćen trombocitima i plazma bogata faktorima rasta u oralnoj kirurgiji [Master's thesis]. Zagreb: University of Zagreb, School of Dental Medicine; 2019 [cited 2024 November 04] Available at: https://urn.nsk.hr/urn:nbn:hr:127:509514

M. Šeba, "Plazma obogaćena trombocitima, fibrin obogaćen trombocitima i plazma bogata faktorima rasta u oralnoj kirurgiji", Master's thesis, University of Zagreb, School of Dental Medicine, Zagreb, 2019. Available at: https://urn.nsk.hr/urn:nbn:hr:127:509514

Metadata
TitlePlazma obogaćena trombocitima, fibrin obogaćen trombocitima i plazma bogata faktorima rasta u oralnoj kirurgiji
Title (english)PLATELET RICH PLASMA, PLATELET RICH FIBRIN AND PLASMA RICH IN GROWTH FACTORS IN ORAL SURGERY
AuthorMirjana Šeba
MentorIvan Zajc (mentor)
Committee memberIvan Zajc (predsjednik povjerenstva)
Committee memberMarko Granić (član povjerenstva)
Committee memberMarko Vuletić (član povjerenstva)
GranterUniversity of Zagreb
School of Dental Medicine
(Department of Oral Surgery)
Zagreb
Defense date and country2019-09-16, Croatia
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Dental Medicine
Oral Surgery
Abstract
Plazma obogaćena trombocitima, fibrin obogaćen trombocitima i plazma bogata faktorima rasta trombocitni su koncentrati koji se dobivaju iz autologne venske pune krvi različitim protokolima centrifugiranja i kasnijom obradom. Ti pripravci razlikuju se u brzinama i trajanju centrifugiranja, dodatku ili odsutnosti aditiva, izdvajanju odreĎenih slojeva te radom u jednoj ili više faza. Trombociti imaju regenerativni potencijal zahvaljujući citoplazmatskim α-granulama iz kojih se oslobaĎaju faktori rasta nakon aktivacije trombocita. Zbog drukčijih načina pripreme izmeĎu PRP-a, PRF-a i PRGF-a postoje mnoge razlike, od onih u udjelu krvnih komponenti u sastavu koncentrata, mehaničkim svojstvima, imunomodulacijskim i osteoinduktivnim svojstvima, količini dobivenog koncentrata, jednostavnosti pripreme, prisutnosti ili odsutnosti fibrinske mreţice (što je povezano s brzinom otpuštanja faktora rasta) pa sve do praktičnosti aplikacije i ekonomičnosti. Trombocitni koncentrati pronašli su svoju upotrebu u mnogim granama medicine zahvaljujući svojoj ekonomičnosti, jednostavnosti pripreme i primjene te učinkovitosti u ubrzavanju cijeljenja. U oralnoj kirurgiji najčešće se primjenjuju kao adjuvantna terapija za postizanje boljih rezultata u postupcima poput prezervacije alveole, horizontalne augmentacije grebena, augmentacije dna maksilarnog sinusa, u implantologiji, zatvaranju oroantralne komunikacije, apikotomiji, cistektomiji, osteonekrozi čeljusti i voĎenoj regeneraciji kosti i tkiva.
Abstract (english)
Platelet rich plasma, platelet rich fibrin and platelet rich growth factor are platelet concentrates derived from autologous venous blood obtained by different centrifuge procedures. The difference in procedures are in speed and duration of centrifugation process, addition or lack of additives, seclusion of layers and in one-step or dual-centrifuge process. Platelets have regenerative potential thanks to cytoplasmic alpha granules that contain growth factors which are released upon activation of platelets. Because of the differences in preparation protocol, PRP, PRF and PRGF have a lot of differences, starting from the difference in percentage of blood components in different platelet concentrates, mechanical properties, immunomodulatory and osteoinductive properties, amount of obtained and usable material, simplicity of preparation protocol, presence or absence of fibrin mesh (which determines the speed of releasing growth factors) to practicality of application and cost effectiveness. Platelet concentrates have found their application in many medical areas thanks to their cost effectiveness, simplicity of preparation and usage and efficiency in deriving of healing processes. In oral surgery, they are used as adjuvant therapy for getting better results in procedures like alveolar socket preservation, horizontal ridge augmentation, maxillary sinus augmentation, in implantology, closing of oroantral communication, apicoectomy, cystectomy, osteonecrosis of jaw and guided bone and tissue regeneration.
Keywords
Keywords (english)
Languagecroatian
URN:NBNurn:nbn:hr:127:509514
Study programmeTitle: dental medicine
Study programme type: university
Study level: integrated undergraduate and graduate
Academic / professional title: doktor/doktorica dentalne medicine (doktor/doktorica dentalne medicine)
Type of resourceText
File originBorn digital
Access conditionsOpen access
Terms of useLicence Attribution-NonCommercial 3.0 Unported (CC BY-NC 3.0) icon
Created on2019-11-07 12:03:44