The World Allergy Organisation (WAO) guidelines has issued guidelines for the initial treatment of anaphylaxis which is defined as a severe, life-threatening, generalized or systemic hypersensitivity reaction. During subsequent exposure to the allergen, mediators from mast cells and basophils are released, resulting in a series of clinical manifestations, most commonly with skin reactions such as urticaria and/or angioedema. One of the main causes of anaphylaxis, apart from the food, is medication or anaesthesia widely administered in dental clinics. Therefore the knowledge of protocol guidelines for management of anaphylaxis is of the utmost importance. The new WAO guidelines have lessened the importance of the second-line medications such as antihistamines, glucocorticoids and bronchodilators, enhancing the emphasis for epinephrine (adrenaline) injection as the first line medication in case of the initial anaphylaxis management. It is necessary to rapidly assess patient’s circulation, airway, breathing, mental status, and skin, simultaneously calling for help. As soon as possible, epinephrine (adrenaline) should be injected intramuscularly in the mid-anterolateral aspect of the thigh; the patient should be placed on the back with the lower extremities elevated. If necessary, administer supplemental oxygen, give intravenous fluid resuscitation, and initiate cardiopulmonary resuscitation with continuous chest compressions. At regular intervals, monitor the patient's blood pressure, cardiac rate and function, respiratory status and oxygenation and, if possible, obtain electrocardiograms. Patients with anaphylaxis refractory to the above measures (requiring intubation and mechanical ventilation or intravenous epinephrine) should be transferred to a healthcare facility where an additional support is available.