Periimplantitis, a common 21st century disease in dental medicine, is caused by various etiological factors ae well as without clear therapeutic guidelines. Under the influence of bacteria, peri-implant healthy tissues turn into peri-implant diseases and conditions. Peri-implant diseases and conditions are peri-implant mucositis and periimplantitis. Peri-implant mucositis is a superficial inflammatory condition of the gingiva around a dental implant. If left untreated, it precedes to periimplantitis. Periimplantitis usually begins painlessly with symptoms of gingival redness, mild swelling, and inflammation of the area around the implant, which results in bleeding and pus. X-rays sometimes show bone loss around the implant. The procedure of rescuing implants affected by periimplantitis includes periodontal treatment with initial therapy as well as with respective and regenerative surgical procedures. Periodontal regenerative surgery is required to achieve re- osseointegration. As a term in the treatment of periimplantitis, re-osseointegration presupposes a complete bone regeneration around the implant that can be aided by various regenerative materials used in the periodontal surgical treatment of periimplantitis. In this clinical case, after detailed diagnosis and initial periodontal therapy, surgery was performed according to the periodontal principles of tissue preservation around the implant, removal of granulation from the bone defect and the implant surface, and mechanical and chemical cleaning of the implant surface before the application of the replacement materials. Healthy probing depths were obtained during the dental checkup, allowing the possibility of osseointegration around the implant. The dental checkup after one year does not show any signs of recurrence of inflammation or possible recurrences, and we can conclude that the goal of treating periimplantitis with the replacement of the lost hard tissues without inflammation is achieved.