Cheilitis refers to lip inflammations of various etiologies. According to a recently suggested classification, the largest group consists mostly of reversible cheilitides that include cheilitis simplex, exfoliative cheilitis, angular cheilitis, contact/eczematous cheilitis, and drug-induced cheilitis. That cheilitis group is of reversible character and can usually be treated easily if the etiologic factors are discovered and removed. Cheilitis simplex and exfoliative cheilitis are most commonly caused by bad habits and cold air which dries out the lips. Moreover, exfoliative cheilitis is also caused by chronic inflammations. Angular cheilitis has the widest etiology which includes infectious agents, licking the corners of the lips, mechanical damage, anatomical variations, and nutrient deficiencies. Contact/eczematous cheilitis is caused by an allergic reaction to a certain substance, while the drug-induced cheilitis occurs because of medications (usually the ones that dry out the lips, such as retinoid). According to the previously mentioned classification, the second group consists mostly of irreversible cheilitides which are persistent and difficult to cure. Although the etiology of cheilitis glandularis and granulomatous cheilitis is unknown, pathophysiology mentions the presence of other diseases and patients’ habits such as smoking and sun exposure. Actinic cheilitis is caused by the cumulative effects of sunlight exposure and usually affects older and lighter-skinned people. The third group of cheilitides is made up of those cheilitides that appear as a part of other dermatoses and systemic diseases, such as lichen, lupus, pemphigus, etc. Because the cheilitis etiology is complex and often overlapping, determining the cause of the inflammation and consequently the accurate treatment can sometimes be difficult. Therefore, treating lip inflammations can occasionally require an interdisciplinary approach. Cheilitides that belong to the irreversible group should be given additional attention because there is a possibility of a malignant alteration.