prikaz prve stranice dokumenta Uporaba hijaluronske kiseline u regeneraciji parodonta
  Download
PDF 926.58 KB
master's thesis
Uporaba hijaluronske kiseline u regeneraciji parodonta
Zagreb: University of Zagreb, School of Dental Medicine, 2020. urn:nbn:hr:127:206427
Hercigonja, Mihaela
University of Zagreb
School of Dental Medicine
Department of Periodontology

Institutional repository: University of Zagreb School of Dental Medicine Repository

Cite this document

Hercigonja, M. (2020). Uporaba hijaluronske kiseline u regeneraciji parodonta (Master's thesis). Zagreb: University of Zagreb, School of Dental Medicine. Retrieved from https://urn.nsk.hr/urn:nbn:hr:127:206427

Hercigonja, Mihaela. "Uporaba hijaluronske kiseline u regeneraciji parodonta." Master's thesis, University of Zagreb, School of Dental Medicine, 2020. https://urn.nsk.hr/urn:nbn:hr:127:206427

Hercigonja, Mihaela. "Uporaba hijaluronske kiseline u regeneraciji parodonta." Master's thesis, University of Zagreb, School of Dental Medicine, 2020. https://urn.nsk.hr/urn:nbn:hr:127:206427

Hercigonja, M. (2020). 'Uporaba hijaluronske kiseline u regeneraciji parodonta', Master's thesis, University of Zagreb, School of Dental Medicine, accessed 19 April 2024, https://urn.nsk.hr/urn:nbn:hr:127:206427

Hercigonja M. Uporaba hijaluronske kiseline u regeneraciji parodonta [Master's thesis]. Zagreb: University of Zagreb, School of Dental Medicine; 2020 [cited 2024 April 19] Available at: https://urn.nsk.hr/urn:nbn:hr:127:206427

M. Hercigonja, "Uporaba hijaluronske kiseline u regeneraciji parodonta", Master's thesis, University of Zagreb, School of Dental Medicine, Zagreb, 2020. Available at: https://urn.nsk.hr/urn:nbn:hr:127:206427

Metadata
TitleUporaba hijaluronske kiseline u regeneraciji parodonta
Title (english)Utilization of hyaluronic acid in periodontal regeneration
AuthorMihaela Hercigonja
MentorDarko Božić (mentor)
Committee memberDarko Božić (predsjednik povjerenstva)
Committee memberAna Badovinac (član povjerenstva)
Committee memberIvan Puhar (član povjerenstva)
GranterUniversity of Zagreb
School of Dental Medicine
(Department of Periodontology)
Zagreb
Defense date and country2020-09-23, Croatia
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Dental Medicine
Abstract
Hijaluronska kiselina sastavni je dio izvanstaničnog matriksa vezivnog tkiva i identificirana je u svim parodontnim tkivima: gingivi, parodontnom ligamentu, cementu i alveolarnoj kosti. Riječ je o biokompatibilnoj, bioresorbilnoj, neantigenoj i neimunogenoj molekuli zbog čega se smatra optimalnim biomaterijalom. In vitro istraživanja pokazala su da hijaluronska kiselina omogućuje visoku stopu preživljavanja stanica parodontnog ligamenta te da dovodi do njihove proliferacije i migracije, a svoje djelovanje ostvaruje putem CD44 receptora. Budući da čini ključnu komponentu tijekom cijeljenja tkiva, provedene su studije o njezinoj kliničkoj primjeni u regeneraciji parodonta. U kliničkim istraživanjima pokazala je antibakterijsko, antiedematozno i protuupalno djelovanje. Hijaluronska kiselina može se koristiti u nekirurškoj terapiji gingivitisa i parodontitisa, regenerativnoj kirurškoj parodontnoj terapiji te mukogingivalnoj kirurgiji. Većina autora pokazala je pozitivan učinak hijaluronske kiseline kao dodatka mehaničkoj terapiji parodontitisa, iako nekoliko istraživanja nije dokazalo značajne rezultate. Hijaluronska kiselina povoljno je djelovala na cijeljenje intrakoštanih defekata nakon kirurške terapije što se očitovalo poboljšanjem parodontnih parametara i radiološki dokazanim dobitkom kosti. Nekoliko studija proučavalo je djelovanje hijaluronske kiseline u kirurškoj terapiji recesija i rezultati su pokazali da je postotak prekrivenosti korijenova bio značajno veći u testnim skupinama. S obzirom na to da su određene studije pokazale oprečne rezultate, potrebno je provesti daljnja istraživanja koja će uključiti histološke preparate i dugogodišnje praćenje kako bi se ustvrdila uloga hijaluronske kiseline u regeneraciji parodonta.
Abstract (english)
Hyaluronic acid is a normal part of the extracellular matrix in the connective tissue and has been identified in all periodontal tissues: gingiva, periodontal ligament, cementum and alveolar bone. It is a biocompatible, bioresorbable, non-antigenic and non-immunogenic molecule, which is why it is considered as an optimal biomaterial. In vitro studies have shown that hyaluronic acid maintains a high level of cell viability and enhances cell proliferation and migration by binding to a specific CD44 receptor. Since hyaluronic acid is a key component during wound healing, studies have been made about its clinical application in periodontal regenerative therapy. Clinical trials have shown that it has anti-bacterial, anti-oedematous and anti-inflammatory properties. Hyaluronic acid can be used in non-surgical therapy of gingivitis and periodontitis, regenerative and mucogingival surgical therapy. Most authors have shown that hyaluronic acid has a positive effect as an adjunct to mechanical periodontal therapy, although some studies have not proven significant results. A positive outcome was recorded in the treatment of intrabony defects when hyaluronic acid was applied, which was proven by increased periodontal parameters and radiographic bone gain. Several studies have examined the usage of hyaluronic acid in the gingival recession surgical treatment and results have shown that the percentage of root coverage was significantly improved in test groups. Since some studies have shown contrary results, further investigations that will include histological analysis and long-term follow-ups are necessary to prove the role of hyaluronic acid in periodontal regeneration.
Keywords
Keywords (english)
Languagecroatian
URN:NBNurn:nbn:hr:127:206427
Study programmeTitle: dental medicine
Study programme type: university
Study level: integrated undergraduate and graduate
Academic / professional title: doktor/doktorica dentalne medicine (doktor/doktorica dentalne medicine)
Type of resourceText
File originBorn digital
Access conditionsOpen access
Terms of useLicence Attribution-NonCommercial 4.0 International (CC BY-NC 4.0) icon
Created on2021-01-21 12:20:47