Environmental pollution can be of natural or anthropogenic origin, and within the specified there is also biological pollution. The causes of biological pollution are invasive species that with the propagation and growth affect the natural ecosystem. This includes Zebra mussel (lat. Dreissena polymorpha). Zebra mussel was discovered in 1796 in the rivers of the Urals, the Volga and the Dnieper. Natural habitat are areas of Central and Eastern Europe, and some Asian countries. From these locations, Zebra mussel has spread (waterway transport, discharge of ballast water) through the rest of the Europe and to the North America. In addition to its harmful effects on the natural ecosystem adverse effect on the industrial infrastructure have also been observed. In this paper Zebra mussel was described and an overview of the several studies about the effects of various chemical compounds on the inhibition of reproduction as well as their mortality was given. The mussels are durable and can quickly adapt and acquire immunity. The most effective ways to suppress economic damage in industrial plants are chlorination of water, heating the water in a presence of the oxidant and the use of copper pipes or coppering of steel pipes. The survey conducted in order to explore the impact of nonylphenol and hypoxia on reproduction and mortality, and the new methods that are still in development are given.