In order to improve the hold and function of dentures for the patient, various prostheses made of metal, mostly metal alloys, are used every day in dental practise. Cobalt-chromium alloys are usually the first choice because they have very good mechanical properties and satisfactory clinical conditions. Nowadays, laser welding is increasingly used in dental practise due to its numerous advantages over other technologies. In this work, therefore, six commercially available Co-Cr alloys were investigated. Three of them are used for metal-ceramic work, two for denture frameworks and one is suitable for both applications. They were joined by laser welding and subsequently analysed microscopically. Their mechanical properties were determined and statistically evaluated. The microhardness of the laser-welded alloys is in the range of 282–465 MPa in the weld zone and between 283 and 435 MPa in the heat-affected zone. The flexural strength of the laser-welded alloys is lower than the control group, but an alloy for the metal-ceramic work (I-BOND NF) shows very similar value. Furthermore, this alloy, together with two other metal-ceramic alloys, survived a maximum of cycles in dynamic tests. It was found that the laser method can be used for joining Co-Cr alloys while ensuring appropriate parameters that guarantee the quality of the dental work.