Technological force is one of the fundamental success factors of a large number of economies and businesses. The ability to innovate processes, products and services is truly one of the most significant impacts on the export competitiveness of enterprises. This could be applied to new products and services, and new technologies, new manufacturing processes, new marketing methods and new models of governance. The ability to introduce innovation into companies could not be successfully realized without investment in research and development. Research and development as a factor in the development of successful innovations in certain groups of companies represents a source of competitive advantage, both at domestic and international markets. Especially in high technology-based industries such as biotechnology, pharmaceutical and computer industries, these types of innovations are often profound. Continuous investment in research and development activities and innovation is not result of the oppurtunity, but a systematic and disciplined analytical thought processes in the context of applied research. Research and development activity (whose product innovation "experiences" the application) has been shown to increase export comeptitiveness of most companies in a particular market. In addition, market demand, costs and business environment are also play a major role as key determinants in research and development and innovation activities of a successful enterprise. The formulation, analysis, testing and evaluating the impact of research and development on the export competitiveness selected enterprises of chemical industry using system GMM (Generalized Method of Moments) estimator of econometric analysis of dynamic panel data represents a special contribution. This confirms the hypothesis that the research and development along with innovation are the most important determinants of export competitiveness of enterprises. The results serve as the basis for the proposing activities, guidelines for improving the export competitiveness of the european chemical industry which represents medium high- and high-tech industries.