Down syndrome is one of the most common genetic disorders that occurs as a result of the presence of an additional 21st chromosome, which leads to a condition known as trisomy 21. This disorder was first described in 1866 by the British physician John Langdon Down, which significantly affects physical, cognitive and social development of individuals. People with Down syndrome have common features such as slanted eyes, small ears and nose, wide neck and dry skin, reduced muscle tone, short arms, reduced head size and various defects. Creative and interactive games and other activities especially help in the development of motor and perceptive abilities, stimulate the emotional and social development of children with Down syndrome. Creative and interactive activities can significantly contribute to the development of motor, perceptual and social skills in children with Down syndrome. Through the analysis of various methods and techniques, the work shows how adapting these activities to the specific needs of children can help in their more successful integration into society and the educational system, while respecting their individual capabilities and limitations. Children with Down syndrome go through childhood and adolescence, study, attend school, and find employment on the labor market. Children should be encouraged and taught from the moment a difficulty is noticed. It should not be imposed on children with Down syndrome what they can and cannot do, they should be given the opportunity to show their possibilities and potential through learning. Therefore, the aim of this paper is to emphasize the importance of early intervention and continuous support for children with Down syndrome and to point out creative activities that stimulate the perceptual-motor skills of children with Down syndrome in order to ensure their optimal development and quality of life.