Background: Infectious diseases are manifested by general and specific symptoms in which pain plays an important role. Aim: The aim of this research was to examine the characteristics of pain and the existing prac-tice of pain management in the acute phase of infectious diseases. Methods: This prospective study, conducted from March to November 2019, included hospi-talized patients diagnosed with erysipelas, cellulitis, herpes zoster, meningoencephalitis or spondylodiscitis. Patients` demographic and clinical data were collected and statistically ana-lyzed. Clinical data included: duration of hospitalization, patient categorization, pain charac-teristics, application of physical therapy, inflammatory parameters, chronic illnesses and ther-apy of chronic illnesses. Nursing interventions carried out in order to decrease pain intensity were also analyzed including: administration of prescribed analgesic, removal of distractors, treatment of skin changes, patient positioning, cryotherapy and elevation of the extremities, calming of patient, wound dressing, application of antiemetics. We also analyzed types of an-algesics and their method of administration during the 24 hours following hospitalization, af-ter which pain intensity was evaluated. Results: A total of 100 participants were included in this research; 48% were women, who reported a higher intensity of pain for all diagnoses except herpes zoster. Pain appeared on average five days prior hospitalization and the difference in the distribution of the number of days from the onset of pain to hospitalization was statistically significant. The highest pain intensity during hospitalization (8/10) was recorded in patients with spondylodiscitis. Half of the patients complained of headache, and the majority reacted to pain by resting. Our research has shown that pain intensity, 6 on average, was higher in the second and third category pa-tients, while in patients allocated to the first category, the pain intensity was on average 4.5. Patients who required a higher level of health care were hospitalized for longer period of time. In order to reduce pain intensity, which on average was 6/10 at the time of hospitalization, a nursing intervention that includes administration of appropriately prescribed analgesic was applied at least once in all patients. In 80% of patients, analgesics were prescribed as needed, and our research results have showed that the most frequently prescribed analgesics were also antipyretics. Evaluation of pain intensity 24 hours after hospitalization showed an average value of 3.5. The results have shown that pain intensity was higher in patients receiving phys-ical therapy who were diagnosed with erysipelas, cellulitis and herpes zoster, than in patients with spondylodiscitis. Leukocyte count and C-reactive protein analysis showed expected val-ues of these laboratory parameters for listed diseases. Conclusion: The analysis of collected data provided insight into the characteristics of pain in the acute phase of infectious diseases and the existing practice of pain management.