This paper deals with the topic of the relationship between business communication and negotiation and the influence of culture on business communication and negotiation. The paper examines the process of communication as a daily need and action along with the importance of mastering communication skills which, as an indispensable part of business negotiation, increases the likelihood of a successful negotiation outcome. The concept of negotiation, types, tactics, golden rules and negotiating ethics are also discussed. How successful the negotiation will be and whether the desired goal will be achieved depends on how well the negotiator mastered communication and negotiation skills and which tactics and strategies will be used in the negotiation process. Since we live in an age where changes in population, travelling, politics, technology and economy made interaction across various cultures necessary, the ability of intercultural communication helps to better understand world events and processes and contributes to improving intercultural cooperation.