Introduction: Humor is a common name for verbal, written and cartoon content that causes laughter and good mood; but at the same time, humor is also defined as a personality trait that manifests itself in wit. Humor, as an important feature for our health, affects both physical and mental health. It helps us defend against stress and negative mood. The coronavirus pandemic has brought various changes to almost every aspect of human daily life, so even social networks were not left out. Everyone wanted to know everything about the new virus and the disease caused by it, and experts and scientists did not have answers to the questions asked by the frightened public. Objective: To investigate how humor affected the respondents in the era of the COVID-19 pandemic during the quarantine. Examining its function as entertainment, medicine and in general coping with the COVID-19 pandemic and presenting the same results statistically and descriptively in this paper. Respondents and methods: 103 respondents aged between 20 and 50 participated in the research via an online survey. Students of the University of Dubrovnik, employees of the Dubrovnik General Hospital and the Dubrovnik Health Center are included. The questionnaire consisted of ten questions. The questions included: gender, age, professional qualification, how much fear is there of infection on a scale of 1 to 10, and the impact of humorous content on the topic of the COVID-19 pandemic. Results: The results of the research showed that as many as 70.9% of respondents stated that with humorous content, time passed faster. The next 39.8% of respondents improved communication with family members, and 33% of respondents improved communication with friends. Discussion: The data obtained from this research show how COVID-19 and the quarantine have affected the lives of people of all age groups. It should be pointed out that similar topics are generally poorly covered, and current literature and similar research were difficult to access. Conclusion: Humor is really a medicine not only in difficult mental moments, but also has a beneficial effect on people's physical health. It behaved as an anxiolytic, and it could even be said as a sedative in some cases. The conclusion is that humor proved to be a medicine during the crisis of the mentioned coronavirus pandemic.