The blue crab, Callinectes sapidus Rathbun, 1896, has been the subject of scientific research for more than 100 years. Most of the initial research on blue crab was briefly described and provided only views on the natural history of crab. Blue crab belongs to the class of ten-legged (decapod) crabs within the family Portunidae. It is native to the Atlantic coast from Nova Scotia, Canada to northern Argentina. Over the past century, they have been recorded in Africa, Asia and Europe, far from their native habitat, and the most likely vector is ballast water intake. The first record in Croatia was a male caught at the mouth of the Neretva in 2004, after which this species is increasingly recorded in other localities south of the place of first introduction. Research on this species in the Adriatic Sea aims to find out whether the species has established a population in a particular location. A significant increase in the abundance of the population of C. sapidus can have serious consequences for native communities, as well as for shellfish aquaculture and fisheries, as this species damages fishing nets as well as the fish caught in them. On the other hand, it is considered a delicacy and has exceptional commercial importance in North America, Europe, and Japan. Therefore, it should be promoted locally as a new food source, which could encourage fishing them and thus reduce its populations and potential negative impacts on native flora and fauna.