Based on the analysis of breast histopathological findings collected over a three-year period through CNB (core needle biopsy) at the General Hospital Dubrovnik, the study revealed the distribution of patients with various B diagnoses, specific prognostic factors for non-invasive and invasive breast carcinomas, and the frequency of findings in the left and right breasts. Core needle biopsy emerged as a significant and irreplaceable diagnostic method, enabling the determination of prognostic and predictive factors prior to further treatment, particularly crucial for patients undergoing neoadjuvant therapy. The research examined 242 patients subjected to core needle biopsies, with the majority diagnosed with invasive carcinoma. Out of all available data, it was found that 210 patients had malignant growths in the sampling site, representing 85% of the total examined findings. The most common sampling sites were in the upper lateral quadrant of the right breast. The importance of determining hormonal and HER2 status was emphasized for therapeutic guidelines. The observed results in our analysis are entirely consistent with existing literature and offer a significant insight into the molecular profile and prevalence of breast cancer in the Dubrovnik area. The findings demonstrate a high level of sophistication in diagnostics and treatment of breast cancer patients at the General Hospital Dubrovnik. Core needle breast biopsy has become an indispensable diagnostic method for breast carcinomas due to its specificity and sensitivity, both globally and at the General Hospital Dubrovnik where it is increasingly performed each year.