The subject of thesis is "The economic and entrepreneurial aspects of wellness tourism" which will explain tourism focused on the economy and entrepreneurship in general and economics and entrepreneurship in wellness tourism. „Tourism as an economic category“ is the part that explains what is economic representation in tourism and also try to explain whom economic activity it belongs. The second part deals with tourism wellness market, with supply and demand, consumption in the wellness market and trends as well, as key factors that maintain the wellness market is one of the most powerful market in the global economy. It explains interdependence of economics and entrepreneurship in tourism, endeavoring to highlight the risks and forms of tourism entrepreneurship and ways of starting an entrepreneurial project. Wellness entrepreneurship and examples of business ideas in the sector is specifically mentioned and all this is described in the third part. Very important and not at all negligible, "A holistic approach to wellness" is the penultimate section of thesis and also the introduction to the final part, respectively research. The research is a work segment which is consisting of fulfilling the questionnaire on "Holistic Center" and describing the results obtained on the basis of hundreds of respondents. This study gives a slight idea of the importance and awareness of people about the holistic approach in Međimurje County.