Contact dermatitis (CD) is skin inflammation that occurs after contact with substances that can irritate skin or cause allergic reaction. It is characterised by itch, rash, redness, swelling and sometimes there can also be vesicles that burst and crusts with content of broken blister. According to etiological division there are different types of contact dermatitis: contact non-allergic dermatitis (acute and chronic), contact allergic dermatitis (acute and chronic), photoallergic contact dermatitis, phototoxic contact dermatitis and contact urticaria syndrome. Clinical features are different. Number of people suffering from CD is increasing. Contact non-allergic or irritative dermatitis is a skin inflammation that occurs after exposure to concentrated alkalis and acids which cause damage to the upper layer of epidermis, without immune mechanisms. Contact allergic dermatitis is an inflammatory skin disease produced by IV type allergic reaction, mediated by lymphocytes. It is equally distributed among males and females. The most important diagnostic methods for allergic hypersensitivity are: anamnesis, clinical picture and skin patch test. The intensity of inflammation depends on many different factors: amount and strenght of the irritant, length and frequency of the exposure, environmental factors etc. It is extremely important to avoid any contact with the allergen and use protective gloves, masks and clothings. Professional contact dermatitis can be of allergic and non-allergic origin, and it is caused by skin contact with many different substances in the working environment. In the development of professional dermatitis informations about profession, potential alergens or irritant, substances in the working place, working conditions, skin condition before starting specific job, protective clothing and other protective things are very important. If allergens cannot be removed or avoided the change of job position or professional retraing might be needed.