This study aimed to examine whether the quality of life in people with a stoma was impaired regardless of the age and sex of the respondents. The research is organized as cross-sectional research. The test was conducted on 27 July 2021 at the regular gathering of members of the ILCO society of Varaždin. 23 respondents participated. To obtain the data, the Quality of life Questionnaire for a Patient with an Ostomy was used, the use of which is free. The data obtained from the research show that the respondents are the least satisfied with physical well-being, and the most with spiritual well-being. Thirty-nine percent of respondents said they found it difficult to adjust to a stoma, and only 30% felt satisfied with life. Also, only 13% of respondents think they control things in their life and are satisfied with their appearance. Due to the increasing incidence of colorectal cancer, the implementation of a prevention program is of great importance. The national program for early detection of colon cancer aims to diagnose the disease early and includes citizens between the ages of 50 and 74. Nurses play a significant role in the patient recovery process. Nurses provide support to the patient, conduct physical and psychological preparation of the patient for surgery, conduct health care and education of the patient and his family. After the patient leaves the hospital, enterostomal therapists continue to take care of patients with stoma, incontinence and chronic wounds.