The Croatian Institute of Emergency Medicine is a public healthcare institution that provides emergency medicine and telemedicine services on the territory of the Republic of Croatia. The Institute of Emergency Medicine of Međimurje County has been operating for nine years. The Institute employs 15 T1 teams, 10 T2 teams, as well as 5 teams in the emergency dispatch unit, and together they cover an area with over 100,000 inhabitants. Prehospital emergency health care workers are more frequently in contact with patients with severe diseases, and specific procedures involving increased aerosol production make them more exposed to the risk of in-fection with the new coronavirus. Therefore, it is important to urgently assess risks and define new work methods and specifics through protocols, guidelines and series of measures. Based on data collected before and during the pandemic, the main goal of this study was to show how the coronavirus had affected the medical emergency dispatch unit, the quality of work of emer-gency medical services and the workload of emergency medical teams in relation to specific work conditions and transport of patients with COVID-19. The analysis of the data collected on patients treated by the Institute’s staff showed that in some work-related segments, there was no statistically significant impact of COVID-19 on the Institute’s operations; e.g. patients meeting the “code red” emergency criteria with almost any kind of condition were treated within the expected time interval in more than 90% of interventions despite the pandemic. On the other hand, some segments were significantly affected by COVID-19 with regard to the treatment of emergency patients in Međimurje County. Aspects of work in which the impact of the pandemic is visible are: extended duration of emergency calls, an increase in the total number of calls and medical and administrative advice given, less field interventions, a longer time period between receiving a call and forwarding the information to the emergency teams, as well as a later dispatch time of emergency teams, an increased number of “code yellow” emergencies and fewer “code red” and “code green” emergencies, a lower success rate of car-dio-pulmonary resuscitation attempts, more time spent on cleaning and disinfection of vehicles and equipment, 9.3% of all emergency interventions and 4% of all ambulance transport were related to coronavirus patients and an increased number of medical cover services provided for vaccination events.