In home health care, medications are used which, according to the patient's condition and needs, are prescribed by a doctor. Home health care workers are required to administer medications only when clearly documented in the care plan. The application of prescribed therapy is performed by medical staff employed in the field of home health care. Sometimes the prescribed therapy can be performed by the patient alone or by a family member, but they need to be educated about the application of the therapy so that the drug is administered correctly and so that its effectiveness is at the highest level. Managing home health care medications is a high-risk, error-prone process where nurses play an important role in maintaining patient safety. In order to create safe health care, nurses need to recognize the challenges they face in the process of administering medications, understand the factors that lead to errors, identify errors, and address them systematically to prevent their future occurrence. As members of the healthcare team, nurses play a key role in the safety of therapy. This job involves preparing the medication, calculating the correct dose, giving the medication to the patient, and monitoring their effects or side effects. Nurses need to acquire the necessary competencies in terms of knowledge and skills in order to act professionally, legally and ethically in relation to the storage, preparation, administration of medicines and their safe disposal. Once they have acquired appropriate theoretical education and practical training, nurses are authorized to administer medication to the patient. Therefore, they must recognize the challenges they face in drug management from preparation to administration and monitoring of associated side effects and have a key role to play in preventing errors that may occur when administering and taking medications.