The wastewater collected by the public sewage system is taken to the wastewater treatment plant and after reaching the required level of treatment, it is discharged into the recipient. The by-product of every technological process of municipal wastewater treatment is sludge, which requires further treatment and disposal in the most technically and ecologically appropriate and at the same time most economical way. The aim of this paper is the analysis of sludge production at the level of Međimurje and Varaždin counties and the analysis of economically acceptable technical and technological solutions for sludge treatment and disposal routes. The topic is very broad, so the focus was placed on four variants of sludge disposal, which were determined by preliminary analyzes to be the most applicable for the area in question. The possibilities of disposal of sludge in agriculture, incineration of sludge in a central mono-incinerator, a variant with simultaneous composting for the area of Varaždin County and use of sludge reed beds for the area of Međimurje County and a variant that includes the export of sludge outside the state borders were analyzed. Based on the analyzes carried out for the described four variants, sludge incineration in a regional mono-incinerator is presented as the most economically advantageous solution, while the variant that includes disposal of sludge in agriculture is shown as the most expensive, but it also predicts the largest range of costs and shows that with the adoption of more rational legislation, that is, by reducing the costs of sampling and analysis of sludge and soil, a much better economic profitability of this variant can be expected. An overview of the legal regulations related to the treatment and disposal of sludge from wastewater treatment plants is also given. Also, general information on sludge content, treatment and disposal methods are presented, as well as information on current sludge disposal procedures in other European countries.