| Title | Komparativna analiza trendova bolničkih infekcija uzrokovanih bekterijom Clostridioides difficile |
| Title (english) | A comparative analysis of trends in hospital infections caused by the bacterial agent Clostridioides difficile |
| Author | Dijana Tuk |
| Mentor | Tomislav Meštrović (mentor) |
| Committee member | Rosana Ribić (predsjednik povjerenstva) |
| Committee member | Tomislav Meštrović (član povjerenstva) |
| Committee member | Marijana Neuberg (član povjerenstva) |
| Granter | University North
(University centre Varaždin)
(Department of Nursing)
Koprivnica |
| Defense date and country | 2022-09-30, Croatia |
Scientific / art field,
discipline and subdiscipline | BIOMEDICINE AND HEALTHCARE
Clinical Medical Sciences
Infectology |
| Abstract | Clostridioides difficile je gram-pozitivna sporogena anaerobna bakterija, štapićastog oblika te
čini dio gastrointestinalne flore čovjeka i životinja. Neki sojevi C.difficile proizvode toksine i
sposobni su uzrokovati blagi do teški proljev i pseudomembranozni kolitis. Nadalje, utvrđeno je
da je bakterija C.difficile čest uzrok bolničkih proljeva povezanih s antibioticima i najčešći je
uzrok infektivnih proljeva u bolnicama i ustanovama za dugotrajnu skrb na globalnoj razini.
Većina slučajeva infekcije bakterijom C.difficile javlja se u bolesnika kojima su propisane
visoke doze antibiotika, ili su im propisani antibiotici tijekom duljeg razdoblja. Stoga, antibiotici
mogu poremetiti normalnu ravnotežu crijevne mikrobiote, mijenjajući njezin sastav i dopuštajući
prekomjerni rast bakterija Clostridioides (Clostridium) difficile Cilj rada je razumijevanje
pojavnosti C.difficile među ljudima i pacijentima u bolnici. Podaci za istraživanje obrađeni su
deskriptivnim metodama, prikazani tablično i grafički, a distribucije kvantitativnih obilježja su
testirane na normalnost D'Agostino-Pearsonovim testom. U promatranom razdoblju unutar 2021.
godine, provedeno je istraživanje pacijenata s C.difficile u Općoj bolnici Varaždin. (Novi
Marof). Dobiveni su vrlo vrijedni rezultati istraživanja koji ukazuju na to da postoje razlike u
pojavnosti C. Difficile između navedenih godina ali da su oboljeli pacijenti stariji od 80 godina.
Zanimljivosti su da nema povezanosti između dobi i mjesta prethodne hospitalizacije i ishod
bolesnika oboljelih od C.difficile nije bio ovisan o spolu ali niti od mjesta prethodne
hospitalizacije. Očekuje se da će se provedba novih istraživanja o C.difficile još bolje rasvjetliti
sve nepoznanice i nejasnoće vezane za ovu infekciju. U tome uvelike mogu pomoći magistre
sestrinstva udružene sa stručnom-znanstvenim kadrom. |
| Abstract (english) | Clostridioides difficile is a gram-positive, rod-shaped, sporogenic anaerobic bacterium that
forms part of the gastrointestinal flora of humans and animals. Some strains of C. difficile
produce toxins and are capable of causing mild to severe diarrhea and pseudomembranous
colitis. Furthermore, C.difficile has been found to be a common cause of hospital-acquired
antibiotic-associated diarrhea and is the most common cause of infectious diarrhea in hospitals
and long-term care facilities globally. Most cases of C.difficile infection occur in patients who
have been prescribed high doses of antibiotics, or who have been prescribed antibiotics for a
long period of time. Therefore, antibiotics can disrupt the normal balance of the intestinal
microbiota, changing its composition and allowing the overgrowth of C.difficile. The research
data were processed using descriptive methods, presented in tables and graphs, and the
distributions of quantitative characteristics were tested for normality with the Agostino-Pearson
test. In the observed period within the year 2021, a survey of patients with C.difficile was
conducted in Varaždin General Hospital.Very valuable research results were obtained, which
indicate that there are differences in the incidence of C. Difficile between the mentioned years,
but that the affected patients are older than 80 years. Interesting facts are that there is no
connection between age and place of previous hospitalization, and the outcome of patients with
C. difficile did not depend on gender, nor on the place of previous hospitalization. It is expected
that the implementation of new research on C.difficile will shed even more light on all the
unknowns and ambiguities related to this infection. In that, nurses with Master's degree may be
very helpful together with expert-scientific staff. |
| Keywords |
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| Keywords (english) |
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| Language | croatian |
| URN:NBN | urn:nbn:hr:122:770581 |
| Study programme | Title: Nursing
Study programme type: university
Study level: graduate
Academic / professional title: magistar/magistra sestrinstva (magistar/magistra sestrinstva) |
| Type of resource | Text |
| File origin | Born digital |
| Access conditions | Open access |
| Terms of use |  |
| Created on | 2023-02-07 10:57:05 |
