Work in social welfare institutions is extremely complex and demanding for all those involved in the process of providing and monitoring the quality of services. Therefore, it is extremely important to understand the way of working and professional cooperation between social care workers and users safely and effectively. One of the tasks of a master's degree nurse is to recognize risks and reduce them to the lowest possible level. Also, the task of the master's degree nurse is to protect and support the patient's health. However, many factors determine their interrelationship: biological factors, behavioral and environmental factors, and socioeconomic factors. Maintaining a high level of patient safety is crucial. Patient safety is an important public health issue defined as the prevention of adverse effects on the patient. The research aims to determine the safety of users in social welfare institutions. During the preparation of the final paper, a retrospective study was conducted, for which the beneficiaries of the Rehabilitation Center Varaždin (N= 539) were used. The research results showed a higher number of cases of pressure ulcers in men (71%) but also a worsening of pressure ulcers (28%). On the other hand, the causative agent of Klebsiella pneumonia infection develops equally in male and female patients (14.9%). It was found that the percentage of autoaggressive behaviors is higher (5%) compared to aggressive behaviors (2%). Also, a moderate percentage of falls among patients during their stay at the Varaždin Rehabilitation Center was determined (7%). One of the most important procedures is patient safety, and to achieve this, quality education and the acquisition of new knowledge in the area of patient safety and protection in social welfare institutions are necessary.