Six Sigma is one of the Management Quality Systems which is the most prominent because of great savings. That savings are also known as return on investment over a certain time period. It is achieved by applying systematic data transmitting which define, measuring, analyzing, improving and controlling. For successful implementation of Six Sigma it is important that the top management of the company or organization actively and dedicated participated in usage of Six Sigma, that understands methodology, tools and technique, connects Six Sigma with business strategy, selects project and monitors their realization, connects Six Sigma whit consumers, organizational infrastructure and suppliers, implement cultural changes and take care of education of employee of the company or organization. The education of employee is the key of success, and thereby return on investment which is important to stakeholders.