INTRODUCTION: „Clostridium difficile (C. difficile) is an anaerobic, gram-positive, spirogenic bacterium that causes antibiotic-associated colitis. Colonization of the intestinal tract takes place by the fecal-oral route and is facilitated by disruption of the normal intestinal flora. Clostridium difficile infection (CDI) is one of the most common nosocomial infections and is a significant cause of morbidity and mortality, especially in elderly hospitalized patients (1). Microorganisms in the altered intestinal environment grow and produce toxins that damage the intestinal mucosa leading to secretion and secretion. Diagnosis is made by finding toxins in the stool, and symptomatic patients are treated with orally appropriate antibiotics (metronidazole, vancomycin) (9).“ OBJECTIVE: To present the role of the nurse in the proven health care of patients with Clostridium difficile infection (CDI). DISCUSSION: To reduce the spread of infection among patients and healthcare professionals, it is necessary to apply anti-epidemic measures to prevent the spread of infection. The attending physician and the head nurse should have taken all prescribed anti-epidemic measures to ensure that patients with Clostridium difficile were organizationally relocated across the ward to a separate patient room, to ensure isolation checks, and to prevent further spread of the dispute. It is important to emphasize that all planned procedures in this patient were performed last in the Department (35). CONCLUSION: The nurse's procedures are aimed at performing all prescribed standard surgical procedures in patients, in order to prevent the spread of Clostridum difficile among hospitalized patients on the ward using all prescribed diagnostic therapeutic procedures prescribed by the physician. The role of the nurse in the implementation of patient education from measures to prevent the spread of isolates, proper nutrition, and hydration procedures is extremely important (35).