INTRODUCTION: It is a fact that almost more than two years have passed since the World Health Organization stated the SARS - CoV - 2 pandemic, the only method to stop the spread of the virus is prophylactic vaccination of the population, and insufficient vaccination can be a major obstacle to suppressing the pandemic. AIM: The aim of the study is to inspect the knowledge and attitudes of nursing students about vaccination against SARS-CoV-2 through cross-sectional research. MATERIALS AND METHODS: The cross-sectional survey was managed online in the period from July 1, 2022 to July 31, 2022. With the help of a questionnaire, 141 undergraduate and graduate nursing students in Croatia were surveyed. THE RESULTS: The sample included 141 respondents, 127 women (90.1%) and 14 men (9.9%), of whom a significant majority (62.4%) were vaccinated against SARS-CoV-2 infection and would advise the same to their relatives ( 56%). The majority of respondents have general knowledge about the vaccine against SARS - CoV - 2 infection (p=0%<5%), and have a mostly positive and positive attitude about vaccination against SARS - CoV - 2 (p=0%<5%). CONCLUSION: Most nursing students are already vaccinated against SARS - CoV - 2, have a positive attitude about the vaccine, have general knowledge about the vaccine and coronavirus disease and its influence on the population in general, and are inclined to advise and recommend vaccination to their relatives.