INTRODUCTION: Acute myocardial infarction is one of the leading causes of death in the developed world, and it is divided into those with or without ST segment elevation. Myocardial infarction is necrosis caused by a sudden decrease in coronary flow to the affected part of the myocardium. OBJECTIVE: To determine the relationship of risk factors to the outcome of percutaneous coronary intervention and to determine the frequency of positive percutaneous coronary interventions in the General Hospital of Šibenik-Knin County. RESULTS: The research was conducted as a cross-sectional study with a convenience sample. Patients hospitalized in the Šibenik-Knin County General Hospital with symptoms of myocardial infarction with or without ST elevation during the 2021 pandemic year were included in the study. Data for this research were extracted from the Hospital Information System after the approval of the Ethics Committee of the Šibenik-Knin County General Hospital. The research was conducted on 119 patients with myocardial infarction, of which 67 (56%) had non-ST-elevation myocardial infarction (NSTEMI), and 51 (43%) had ST-elevation (STEMI). In terms of gender, men are more represented, 81 (68%) compared to women. The median age of patients is 71 years. 19 (17%) patients recovered from COVID-19, and 42 (36%) were vaccinated. Percutaneous coronary intervention without stenting was performed in 25 (21%) patients, and in 74 (62%) percutaneous coronary intervention with stenting. Aortocoronary bypass was performed in three (3%) patients. DISCUSSION:By searching professional databases, papers were found with the results of similar research that confirmed the results of this research. Namely, the same risk factors were determined, only with a different ratio and gender. CONCLUSION: The analysis of the results confirmed known risk factors that were present in almost all patients, which indicates the need for active prevention measures and action on modifiable risk factors.