Raising healthy and functional calves represents the main goal of livestock production. But, since calves are quite sensitive in early age, it is quite common for pathological conditions to occur. Mainly, the problem is in the form of diarrhea caused by infectious or non – infectious agents. These conditions often require veterinary care which can lead to high costs and losses. Also, the overuse of antibiotics contributes to growing antibiotic resistance. Nowadays, for reasons mentioned above, the strategy to combat this problem is mostly oriented on prevention. A significant amount of research investigated the possibility of using natural supplements, which would have to prevent diarrhea or shorten its duration. Today, the most common additives are probiotics, tannins and essential oils and their combinations. In this paper various strategies for prevention of calf diarrhea were presented, each with quite satisfying results. Dose was the most important factor on which the performance depended. Scientists and nutritionists still have a big challenge in finding an ideal or at least most effective solution. Still it`s important to emphasize that the basis of healthy calves lies in good management with high standards. This means high quality rations which include colostrum, milk replacers and dry feed and good farm management and welfare.