OBJECTIVES: During the history medicine primary goal was improving rate of survival and in the case of the disease to have quality treatment. Moreover, medicine science on the basis of the developing technologies and science itself is improving life quality and therefore has a central role in improving the population’s health. From there most important step of each health system is prevention and trough this intervention diseases are avoided and the money is saved. Although today scientific community still hasn’t confirmed that gut flora disbiosis is contributor or consequence of the metabolic and or immunity diseases, we know that long term of use of sub therapeutic doses of antibiotic resistance is developed within bacterias and it is dangerous for the health of the people and animals. Since 1st of January, 2006. in the modern production of the animals used for food within the EU, based on the declaration 355/2003 from 20th February, 2003. it is forbidden to use antibiotics in non clinical cases for the animals as a promotor the growth in the animal’s food. In addition to that, 13th of September, 2018. resolution of the EU parliament was accepted regarding European action plan “One health”. One health presumes improvement of the health systems within the members states with the goals of lowering the risk of diseases caused by resistant bacterias and managing the risks of the food safety. For exactly the same reason pig’s farming efforts are increasing to understand better and to diagnose intestinal infection, including biology of the pathogen, residency and immunomodulatiuon strategy of the late mentioned. Healthy digestive tract maintenance is of the outmost importance since it is dependable of the homeostasis within intestinal mucosa and microbiome. Since the law has prohibited the use of the antibiotic growth promotors in pig’s farming, alternative strategies are taking place that are with scientific background recommendations including additives of biological nutrients that will have protective impact on the animal health, maintainable for the high production and ecological neutral. in the light of the Carob’s fruit and pods’ multiple bioactive components, like simple phenols, polyphenols, free flavonoids, glycosilated flavonoids, for veterinarian’s medicine it is important to investigate carob potential as nuticeutick with the purpose of intestinal health protection and overall immunity of the weened piglets. Carob’s pharmacological and nutritive potentials are well known since the antic times. Good nutrient value of the carob’s fruit consist of sugar (46%), polyphenols (20%) and proteins (7%) which his why its pleothropic pharmacological impact was easy to confirm in the scientific studies. It is worth to mention that carob is also rich in the fibres (40%) that are, for both animals and humans, healthy and have positive impact against pathophysiological and pathological conditions. Carob is taking more and more central spot in the veterinarian science, mainly as the model of the nutrient modulation of the farmed animals. From the pectins to the lignins positive impact on the gut flora and as a stabiliser of the digestion, carob is a great remedy for combating enteritises and inflammation’s of the gut mucosa, dispepsy or constipation. In addition, wast majority of the studies have confirmed that as a food additive, carob, has antiaterogenic, antibacterial, anti microbial, anti fungal, anti diabetic and anti-inflammatory action. As a result of all mentioned above carob is listed, in the EU register of additives, as the additive for all types of animals. Moreover, when the antibiotic usage is forbidden by the law, one of the possible alternative strategy for the prevention and disease control in the farming animals could be adding of the carob in the animal food. HYPOTESIS: Hypothesis of dissertation is that in production systems of the swine, carob (Ceratonia Siliqua) added to the daily meal for the weaned piglets has protective impact on the health and the positive impact on the production and the meat quality. MATERIALS AND METHODS: For the purpose of the investigation on the impact of the dried carob’s additive on the health and production of the weaned piglets, sample of 60 weaned piglets (mixed of Swedish Landras/Yorkshire), 30 females and 30 castrated males, equal weight of 7 kg, old from 28 to 70 days from the population of the family farm Živkovic farm, Kvarte, Perušić. During the whole study weaned piglets’ food (standard mixture SO-1 up to 50 kg) and water we accessible ad libitum. Animals had their health status assessed before entering the study and they were placed in the experiment confined 48 hours before study started. Animals were further divided in the two groups (control and trial group), each group had 30 animals (15 females and 15 males), and they have been marked with the ear tags. They were hold in the confinement of the intensive breeding. Controlled group (group C) was feed with standard mixture without carob’s add, while experimental group (group T) had in the daily meal added 4 (four) % dried carob’s additive. During six (6) weeks of the trial all animals were followed by the parameters that have included food conversion, diarrhoea (start, severeness and length) diarrhoea score, chemical analysis of the meat and health (daily clinically follow up on the health of the animals, haematological investigations in two weeks gaps and bacteriological analysis of the rectum mucosa, pathohistology sampling of the jejunum, ileum and mesenteric lymph nodules. Body weight and feed intake were measured weekly at group level to determinate average daily weight gain, feed intake and feed conversion ratio. Mortality and health status were visually observed and recorded daily trough the trial period. Swabs of the rectal mucosa for the bacteriological analysis have been taken with the sterile swabs 0, 14, 28 and 42 days of the trial from seven (7) animals of the each group. For the each sample total number of the bacteria was measured (CFU, colony forming units) with the standard procedure of the double serial dilution from 101 to 1010 in physiological fluid (horizontal method for the evaluation of the number of the microorganism) and cultivating on the selective and non selective feeding dishes. Samples of the peripheral blood from each animal were taken trout vene punction from v. jugular’s in the sterile tubes with anticoagulant (for haematological, immunehematological and immune analysis) or without anticoagulants (for serological tests) 0, 14, 28 and 42nd day of the trial. Haematological parameters (erythrocytes, leukocytes, thrombocytes, hemoglobin, haematocrit, MCV, MCH, MCHC) are tested with standard methods with automatic haematology analysator ABACUS JUNIOR (Diatron, MI PLC, SAD). Percentage of the differential blood cells (differential blood count) were measured with microscope (Olympus BX 41 on immerse enlargement) seen with stained weaned piglets’ peripheral blood. Biochemical parameters (total serum proteins, blood glucose, urea, cholesterol, triglycerides, albumins, liver enzymes: alkaline phosphatase (ALP), aspartate aminotranspherase (AST), alanine aminotranspherase (ALT), gamma glutamil tranferase (GGT) ) are measured with the standard methods trough biochemistry analyser Beckman Coulter AU 680 (Beckman Coulter Biomedical Ltd Ireland). T lymphocytes (CD45+ and CD3e+) and B lymphocytes (CD45+, CD3eCD21+) we measured with flow citoketer Beckman Coulter Navies (Beckman Coulter Biomedical Ltd Ireland). Phagocytosis and microbiocid properties of monocytes and granulocytes are measured trough modified method after LUKAČ and others (1994.). Spectrophotometic method was used ti measure haptoglobin (HpG) in the serum of the weaned piglets with the test of the Olympus company (OSR6165). Imunoenzimatic sandwich test was used to measure the level of C reactive protein (CRP) with Trident “Phase”™ reagent for the swine CRP (Tridewlta Ltd Ireland). Chemical meat analysis was sampled from the seven (7) animals from the each group. At the end of the trial during animal slaughter, after processing of the meat and cooling (24 hours to 4 celsius degree) samples were taken from the anatomical position of the m. semimembranaceus, on the right/left side to determinate: water (referent gravimetric method ISO 1442), fat (method ISO 1443), proteins (method ISO 937), dust (method ISO 936), cholesterol (ELISA). Statistic analysis of the data was done trough SAS 9.4 program package (2002-2012 SAS institute Inc, Cary, NC, USA). RESULTS: Adding 4% Carob additives to daily feed during six (6) weeks in weaned piglets has positive impact on the end results of the body mass, growth intensity, feed intake and conversion (transformation of the feed unit into the mass growth). It was confirmed that the piglets from the group T (feed with the 4% Carobs additive added to the feed) has bette average daily feed intake (+15%), bigger daily average body mass rise (10%), statistical significant higher body weight in comparison to day 0. (+92%), lower feed usage (conversion) (-9%) in comparison to the piglets from the control group. In the control group during whole time of the trial 13 piglets had diarrhoea that was moderate, except on the 13th day of the trial when three (3) piglets had moderate diarrhoea at the same time. In the group T only two (2) animals developed diarrhoea that lasted one (1) day (one animal developed diarrhoea on 15th day of the trial) to two days (one animal 12th and 13th day of the trial) and it was mild diarrhoea only. Moreover, Carob added to the feed had impact on the diarrhoea occurrence which was only mild and without lethal outcomes in comparison to the control group. In the same time period in the group that was feed with Carob additive, it was recorded lower number of the total number of the bacterias in the digestive tract and negative findings pathogenic E. coli and Salmonella sp. On 42nd day of the trial piglets of the control group had statistically more recognisable number of the CFU/mL in the rectal swab samples (10-5 CFU/ml) in comparison to the group T (10-4 CFU/mL). Secondly positive impact of the Carob additive was confirmed for maintenance of the homeostasis between gut flora in feed weaned piglets. Added Carob to the feed during the whole trial had no impact on the hemogram and erythrocytes levels, biochemical levels which clearly demonstrates that it has no unwanted side effects. It is worth mentioning that Carob had impact on triglyceride’s level (-37.5%) and cholesterol level (-22.7%) in the serum of the weaned piglets fed with Carob additives. During measurements of the proteins of the acute phase as a markers of the health and well being and therefore productivity of the piglets during the trial, in comparison to the weaned piglets from the control group, in the group T treated with Carob it was recorded drop in HpG-a 14th, 28th and 42nd (0.27 – 0.31 g/L) that were still within the normal levels for the weaned piglets. In addition it was recorded rise in the CRP levels in the control group at the end of the trial and drop in the levels of the CRP in the group T. Carob in the meat of the weaned piglets have contributed to lower levels of the total fat (-8.31%) and cholesterol (-7.4%). In the feed added Carob has stimulated number of CD45+, CD4+, CD8+ and CD21+ lymphoid cells in the peripheral blood, meaning it had good impact on phagocytosis and micpoboiocid action of the granulocytes and monocytes in the feed with Carob additives piglets. At the end off the trial piglets that were feed with the Carob additives in the peripheral blood had more typhoid cells in comparison to control group; respectively 18.3% CD45+, 27.7% CD4+, 20.5% CD8+ and 21.1% CD21+. At the end of the trial monocytes showed better fagocitosis for 14.1%, they showed bigger index of ingestion (+13.07%) and had better microbiocidic properties (+11.8%) in comparison to the non Carob fed group. CONCLUSION: Adding all the parameter in this trial hypothesis was confirmed that in the production breeding systems of the pigs, Carob (Ceratonia siliqua L.) added in the daily feed for the weaned piglets has been showed positive nutriceutic and imunomodulator and has positive impact on the health and productivity followed by the meat quality f the weaned piglets.