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master's thesis
Utjecaj polimorfizma TLR4 gena na sastav i kvalitetu mlijeka u mliječnih krava
Zagreb: University of Zagreb, Faculty of Veterinary Medicine, 2024. urn:nbn:hr:178:025490
Oštrić, Bruno
University of Zagreb
Faculty of Veterinary Medicine

Institutional repository: Repository of Faculty of Veterinary Medicine

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Oštrić, B. (2024). Utjecaj polimorfizma TLR4 gena na sastav i kvalitetu mlijeka u mliječnih krava (Master's thesis). Zagreb: University of Zagreb, Faculty of Veterinary Medicine. Retrieved from https://urn.nsk.hr/urn:nbn:hr:178:025490

Oštrić, Bruno. "Utjecaj polimorfizma TLR4 gena na sastav i kvalitetu mlijeka u mliječnih krava." Master's thesis, University of Zagreb, Faculty of Veterinary Medicine, 2024. https://urn.nsk.hr/urn:nbn:hr:178:025490

Oštrić, Bruno. "Utjecaj polimorfizma TLR4 gena na sastav i kvalitetu mlijeka u mliječnih krava." Master's thesis, University of Zagreb, Faculty of Veterinary Medicine, 2024. https://urn.nsk.hr/urn:nbn:hr:178:025490

Oštrić, B. (2024). 'Utjecaj polimorfizma TLR4 gena na sastav i kvalitetu mlijeka u mliječnih krava', Master's thesis, University of Zagreb, Faculty of Veterinary Medicine, accessed 17 November 2024, https://urn.nsk.hr/urn:nbn:hr:178:025490

Oštrić B. Utjecaj polimorfizma TLR4 gena na sastav i kvalitetu mlijeka u mliječnih krava [Master's thesis]. Zagreb: University of Zagreb, Faculty of Veterinary Medicine; 2024 [cited 2024 November 17] Available at: https://urn.nsk.hr/urn:nbn:hr:178:025490

B. Oštrić, "Utjecaj polimorfizma TLR4 gena na sastav i kvalitetu mlijeka u mliječnih krava", Master's thesis, University of Zagreb, Faculty of Veterinary Medicine, Zagreb, 2024. Available at: https://urn.nsk.hr/urn:nbn:hr:178:025490

Metadata
TitleUtjecaj polimorfizma TLR4 gena na sastav i kvalitetu mlijeka u mliječnih krava
Title (english)Influence of TLR4 gene polymorphism on the composition and quality of milk in dairy cows
AuthorBruno Oštrić
MentorMaja Maurić Maljković (mentor)
MentorIvan Vlahek (mentor)
Committee memberVelimir Sušić (predsjednik povjerenstva)
Committee memberSven Menčik (član povjerenstva)
Committee memberMaja Maurić Maljković (član povjerenstva)
Committee memberIvan Vlahek (član povjerenstva)
GranterUniversity of Zagreb
Faculty of Veterinary Medicine
Zagreb
Defense date and country2024-09, Croatia
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Veterinary Medicine
Animal Production and Biotechnology
Abstract
Mastitis je vrlo važniji problem koji dovodi do velikih ekonomskih gubitaka u mliječnoj industriji diljem svijeta. Liječenje mastitisa je teško i skupo te se, stoga, selektivnim uzgojem nastoji poboljšati otpornost na mastitis. Toll like receptori (TLR) su sastavni dio imunosnog sustava, to su transmembranske bjelančevine koje prepoznaju sastavne dijelove raznih patogena i aktiviraju imunološki odgovor. Toll like receptor 4 (TLR4) prepoznaje lipopolisaharide koji su sastavni dio mnogih Gram-negativnih bakterija, a i nekih Gram-pozitivnih bakterija. Iako postoje mnoga istraživanja, njegovi temeljni molekularni mehanizmi i uloga u pojavi mastitisa nisu jasni. U ovom radu istraživana je prisutnost, učestalost i utjecaj polimorfizma c.9421 C>T TLR4 gena na sastav mlijeka i BSS u prvoj laktaciji holštajn frizijskih krava. Polimorfizam je prisutan u istraživanih krava s jednakom učestalosti oba alela (0,5) i najučestalijim TC genotipom. Nisu pronađene statistički značajne razlike za količinu mlijeka, mliječne masti i bjelančevina, udio mliječne masti i bjelančevina te BSS među genotipovima istraživanog polimorfizma. Navedeni nedostatak statistički značajne razlike može biti uzrokovan malim brojem krava u konačnoj analizi.
Abstract (english)
Mastitis is a very serious problem that leads to large economic losses in the dairy industry worldwide. Treatment of mastitis is difficult and expensive, therefore selective breeding is used to improve the resistance to mastitis. Toll-like receptors (TLR) are an integral part of the immune system, they are transmembrane proteins that recognize components of various pathogens and activate the immune response. Toll like receptor 4 (TLR4) recognizes lipopolysaccharides, which are an integral part of many Gram-negative bacteria and some Gram-positive bacteria. Although there are many studies, its underlying molecular mechanisms and role in the occurrence of mastitis are still unclear. In this study, we investigated the presence, frequency and influence of the c.9421 C>T TLR4 gene polymorphism on milk composition and somatic cell count (SCC) in the first lactation of Holstein Friesian cows. The studied polymorphism had an equal frequency of both alleles (0.5). The most frequent genotype was TC. Statistically significant differences were not found for milk, fat and protein qunatities, fat and protein shares, and SCC between the genotypes. This lack of statistically significant difference may be caused due to the small number of cows in the final analysis.
Keywords
Keywords (english)
Languagecroatian
URN:NBNurn:nbn:hr:178:025490
Study programmeTitle: Veterinary Medicine
Study programme type: university
Study level: integrated undergraduate and graduate
Academic / professional title: doktor/doktorica veterinarske medicine (doktor/doktorica veterinarske medicine)
Type of resourceText
File originBorn digital
Access conditionsOpen access
Terms of useLicence In copyright icon
Created on2024-10-30 09:33:09