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master's thesis
Patohistološke osobitosti jetara kod fascioloidoze jelena običnoga i svinje divlje
Zagreb: University of Zagreb, Faculty of Veterinary Medicine, 2019. urn:nbn:hr:178:068391
Škvorc, Nikolina
University of Zagreb
Faculty of Veterinary Medicine
Department of Veterinary Pathology

Institutional repository: Repository of Faculty of Veterinary Medicine

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Škvorc, N. (2019). Patohistološke osobitosti jetara kod fascioloidoze jelena običnoga i svinje divlje (Master's thesis). Zagreb: University of Zagreb, Faculty of Veterinary Medicine. Retrieved from https://urn.nsk.hr/urn:nbn:hr:178:068391

Škvorc, Nikolina. "Patohistološke osobitosti jetara kod fascioloidoze jelena običnoga i svinje divlje." Master's thesis, University of Zagreb, Faculty of Veterinary Medicine, 2019. https://urn.nsk.hr/urn:nbn:hr:178:068391

Škvorc, Nikolina. "Patohistološke osobitosti jetara kod fascioloidoze jelena običnoga i svinje divlje." Master's thesis, University of Zagreb, Faculty of Veterinary Medicine, 2019. https://urn.nsk.hr/urn:nbn:hr:178:068391

Škvorc, N. (2019). 'Patohistološke osobitosti jetara kod fascioloidoze jelena običnoga i svinje divlje', Master's thesis, University of Zagreb, Faculty of Veterinary Medicine, accessed 21 December 2024, https://urn.nsk.hr/urn:nbn:hr:178:068391

Škvorc N. Patohistološke osobitosti jetara kod fascioloidoze jelena običnoga i svinje divlje [Master's thesis]. Zagreb: University of Zagreb, Faculty of Veterinary Medicine; 2019 [cited 2024 December 21] Available at: https://urn.nsk.hr/urn:nbn:hr:178:068391

N. Škvorc, "Patohistološke osobitosti jetara kod fascioloidoze jelena običnoga i svinje divlje", Master's thesis, University of Zagreb, Faculty of Veterinary Medicine, Zagreb, 2019. Available at: https://urn.nsk.hr/urn:nbn:hr:178:068391

Metadata
TitlePatohistološke osobitosti jetara kod fascioloidoze jelena običnoga i svinje divlje
Title (english)Pathohistological Characteristics of Livers in Red Deer and Wild Boar with Fascioloidosis
AuthorNikolina Škvorc
MentorIvan-Conrado Šoštarić-Zuckermann (mentor)
MentorDean Konjević (mentor)
Committee memberMarko Hohšteter (predsjednik povjerenstva)
Committee memberIvan-Conrado Šoštarić-Zuckermann (član povjerenstva)
Committee memberDean Konjević (član povjerenstva)
GranterUniversity of Zagreb
Faculty of Veterinary Medicine
(Department of Veterinary Pathology)
Zagreb
Defense date and country2019-09-17, Croatia
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Veterinary Medicine
Veterinary Clinical Sciences
Abstract
Metilj Fascioloides magna je nezavičajna vrsta parazita na našim prostorima pa unatoč činjenici da je jelen obični naveden kao tipični nositelj, možemo govoriti o razmjerno nedavno uspostavljenoj zajednici nositelj-parazit, dok svinja divlja predstavlja nositelja tipa slijepe ulice. Predilekcijsko mjesto parazitiranja ovoga metilja je jetra u kojoj on migracijom narušava strukturu jetrenog tkiva, dok jetra reagira obrambenim mehanizmima. Prikupljeno je 29 jetara jelena običnoga iz četiri županije (Vukovarsko-srijemska, Požeško-slavonska, Sisačko-moslavačka i Bjelovarsko-bilogorska) iz kojih je izdvojeno ukupno 58 pseudocista te 4 jetre svinje divlje iz Sisačko-moslavačke županije iz kojih su izdvojene 4 lezije indikativne za invaziju metiljem. Histološki preparati izrađeni su iz odabranih područja uzoraka koja su obuhvaćala većim dijelom stjenku pseudociste i okolno tkivo nakon čega su obojani metodama H&E i van Gieson. Izmjerene su debljina stjenke i promjer pseudociste te je određena količina jajašaca, upalnog infiltrata, pigmenta te postojanje znakova mineralizacije. Neinvadirane jetre svinje divlje imaju razvijenije vezivno tkivo u odnosu na jetre jelena običnoga. U upalnom infiltratu invadiranih jetara jelena običnoga prevladavaju limfociti, a zatim slijede neutrofili i eozinofili, dok kod svinje divlje prevladavaju eozinofili, a zatim neutrofili i limfociti. Ovisno o spolu, vrijednosti minimalne debljine stjenke pseudociste s porastom njenog promjera kod košuta padaju, a kod jelena rastu. Utvrđene su promjene na okolnim krvnim žilama, zadebljanje medije većine arterija te proširenje sinusoida. Najčešći nalaz u šupljini pseudociste je nekrotični debris, a uz njega jajašca i pigmentne granule. Ovo je prvo istraživanje koje sistematično pristupa opisu i stupnjevanju mikroskopskih lezija uzrokovanih metiljem F. magna u jetri jelena običnoga i svinje divlje.
Abstract (english)
Fascioloides magna is a non-native trematode species in Croatia. Despite the fact that the red deer is a definitive final host, we can classify this relationship as a recently established host-parasite association. Wild boar is classified as a dead-end host. The migration of young flukes through the liver induces extensive tissue damage, while liver responds initiating various defence mechanisms. We collected 29 samples of red deer livers from four counties (Vukovarsko-srijemska, Požeško-slavonska, Sisačko-moslavačka, and Bjelovarsko-bilogorska) from which 58 pseudocysts were isolated and 4 wild boar livers originating from Sisačko-moslavačka County, with 4 isolated lesions suggestive to be caused by flukes. Histological preparations were made from selected areas that cover most of the wall of pseudocysts and surrounding tissues. Sections were stained using H&E and van Gieson methods. Non-infected wild boar livers have more pronounced connective tissue than those of red deer. Inflammatory infiltrate in red deer livers contains predominantly lymphocytes, followed by neutrophils and eosinophils. In wild boar it is formed of mainly eosinophils, followed by neutrophils and lymphocytes. According to sex, minimal values of pseudocyst wall thickness in hinds decreases with pseudocyst diameter, while it increases in males. Thickening of blood vessels media and dilatation of sinusoids was observed in areas surrounding pseudocysts. The most common finding in the pseudocyst included necrotic debris, fluke’s eggs, and pigmented granules. This is the first study that systematically describes microscopic lesions caused by F. magna in the livers of red deer and wild boar.
Keywords
Keywords (english)
Languagecroatian
URN:NBNurn:nbn:hr:178:068391
Study programmeTitle: Veterinary Medicine
Study programme type: university
Study level: integrated undergraduate and graduate
Academic / professional title: doktor/doktorica veterinarske medicine (doktor/doktorica veterinarske medicine)
Type of resourceText
File originBorn digital
Access conditionsOpen access
Terms of useLicence In copyright icon
Created on2020-01-28 12:22:16