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master's thesis
Tipovi limfoma i njihovo značenje kod pasa - pregledni rad
Zagreb: University of Zagreb, Faculty of Veterinary Medicine, 2020. urn:nbn:hr:178:849198
Klobučar, Sara
University of Zagreb
Faculty of Veterinary Medicine
Department of Veterinary Pathology

Institutional repository: Repository of Faculty of Veterinary Medicine

Cite this document

Klobučar, S. (2020). Tipovi limfoma i njihovo značenje kod pasa - pregledni rad (Master's thesis). Zagreb: University of Zagreb, Faculty of Veterinary Medicine. Retrieved from https://urn.nsk.hr/urn:nbn:hr:178:849198

Klobučar, Sara. "Tipovi limfoma i njihovo značenje kod pasa - pregledni rad." Master's thesis, University of Zagreb, Faculty of Veterinary Medicine, 2020. https://urn.nsk.hr/urn:nbn:hr:178:849198

Klobučar, Sara. "Tipovi limfoma i njihovo značenje kod pasa - pregledni rad." Master's thesis, University of Zagreb, Faculty of Veterinary Medicine, 2020. https://urn.nsk.hr/urn:nbn:hr:178:849198

Klobučar, S. (2020). 'Tipovi limfoma i njihovo značenje kod pasa - pregledni rad', Master's thesis, University of Zagreb, Faculty of Veterinary Medicine, accessed 21 December 2024, https://urn.nsk.hr/urn:nbn:hr:178:849198

Klobučar S. Tipovi limfoma i njihovo značenje kod pasa - pregledni rad [Master's thesis]. Zagreb: University of Zagreb, Faculty of Veterinary Medicine; 2020 [cited 2024 December 21] Available at: https://urn.nsk.hr/urn:nbn:hr:178:849198

S. Klobučar, "Tipovi limfoma i njihovo značenje kod pasa - pregledni rad", Master's thesis, University of Zagreb, Faculty of Veterinary Medicine, Zagreb, 2020. Available at: https://urn.nsk.hr/urn:nbn:hr:178:849198

Metadata
TitleTipovi limfoma i njihovo značenje kod pasa - pregledni rad
Title (english)Types of Lymphoma and Their Significance in Dogs
AuthorSara Klobučar
MentorAndrea Gudan Kurilj (mentor)
Committee memberMarko Hohšteter (predsjednik povjerenstva)
Committee memberAndrea Gudan Kurilj (član povjerenstva)
Committee memberBranka Artuković (član povjerenstva)
GranterUniversity of Zagreb
Faculty of Veterinary Medicine
(Department of Veterinary Pathology)
Zagreb
Defense date and country2020-02-21, Croatia
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Veterinary Medicine
Veterinary Clinical Sciences
Abstract
Limfom predstavlja najčešću grupu novotvorevina kod pasa te se najčešće javlja u srednjoj i starijoj dobi. Iako se često promatra kao jednostruka bolest, ona zapravo obuhvaća brojne klinički i morfološki različite oblike neoplazije limfoidnih stanica. Točan uzrok nastanka ove bolesti nije poznat, ali se smatra da okolišni faktori i genetska osjetljivost igraju važnu ulogu. Najčešće se pojavljuje u multicentričnom obliku, srednjeg do visokog stupnja malignosti, češće porijekla B limfocita. Konačna dijagnoza obično se bazira na aspiracijskoj citološkoj pretrazi, biopsiji i/ili histopatologiji, koju upotpunjavaju druge pretrage kao što su rendgenološka i ultrazvučna, pretrage krvi i mokraće, PCR i biomarkeri. Protokoli terapije s više lijekova koji kombiniraju ciklofosfamid, doksorubicin, vinkristin i prednizolon rezultiraju najvećom stopom i najduljim trajanjem odgovora te čine osnovu za većinu trenutnih protokola koji se koriste za liječnje limfoma. Prognoza ove bolesti ovisi o brojnim čimbenicima, a najbitniji se smatraju imunofenotip, stadij bolesti te odgovor na kemoterapiju,a prosječno preživljavanje je 10- 14 mjeseci. Veliki problem predstavlja otpornost limfoma na lijekove te bi značajan bio razvoj tretmana kojima bi se zaobišla ova pojava.
Abstract (english)
Lymphoma is a most common cancer in middle- aged and older dogs. Altrough is often viewed as single disease, lymphoma actually include a many clinical and morphologic different type of lymphoid cell neoplasia. The cause of lymphoma in dogs is not known but it is considered that environmental factors and genetic sensibility have important role in lymphoma formation. Most common type of lymphoma in the dog is multicentric lymphoma, medium to high grade of malignancy, more often origin of B lymphocytes. Definitive diagnose is based on fine needle aspiration, biopsy and/or hystopatology, in addition witch some other testing like X-rays and ultrasound, blood and urin test, PCR and biomarkers. Therapy protocol with few medicine such as Cyclophosphamide, Vincristine and Prednisolone result in the highest rate and the longest response time and these form the basis of the majority protocol for lymphoma treatment. Prognosis of these disease depend on a number of factors and the most immportant is imunophenotype, stage of disease and response on chemotherapy. Expected survival is 10-14 months. The problem is that lymphoma is resistant on chemoterapeutic and significant would be the development of treatments that would circumvented this phenomenon
Keywords
Keywords (english)
Languagecroatian
URN:NBNurn:nbn:hr:178:849198
Study programmeTitle: Veterinary Medicine
Study programme type: university
Study level: integrated undergraduate and graduate
Academic / professional title: doktor/doktorica veterinarske medicine (doktor/doktorica veterinarske medicine)
Type of resourceText
File originBorn digital
Access conditionsOpen access
Terms of useLicence In copyright icon
Created on2020-11-11 11:48:50