Modulatory effects of native propolis, preparation of white button mushroom and β-glucan on immune and production parameters in weaned pigs Aim: since 2006 European-wide directives are restricting non-clinical use of antibiotic growth promoters (AGP) in food animal production, particularly in swine. The problem of increased sanitary problems in intensive swine production have been overcome thus far by adding subtherapeutic doses of AGP in-feed to enhance production efficiency and prevent/control enteric infections. To accommodate the withdrawal of AGP it now becomes urgent to provide relevant health criteria and scientifically founded recommendations for alternatives. Besides vaccination, these strategies include use of immune response modifiers (IRMs), natural substances with immunomodulatory and bactericidal properties. Thus, the objectives of this dissertation are to find out technically and economically applicable alternatives to to in-feed AGP among IRMs (propolis, preparation of white button and yeast's β-glucan), based on their effects on immune (in vivo and in vitro), health and productivity parameters in weaned pigs. Methodology: 90 weaned pigs (Swedish landrase x Yorkshire) 28 days old were divided in three groups of 30 animal: group A served as a control group and was fed with standard food for weaned pigs; group B was fed with standard food plus preparation of white button mushroom, while group C recieved native propolis with standard food. The experiment lasted 28 days, animals were scaled once a week, and blood samples were collected on weekly base (days 7, 14, 21 and 28), in order to establish productive, health and immunological status of animals in research. Results: group B had the best productive results (the best average weight on day 28). Both of the tested preparations resulted in similar immunological effects (increased values of tested immunological parameters in experimental groups compared to control group). Observed health indicators were slightly better in both experimental groups compared to control group, but the values were within physiological range for species included in research. Conclusion: both experimental preparations showed equally good immunomodulatory effect, but preparation of white button mushroom had better nutraceutical effect.