This paper deals with the history of donkeys, breeds and their current situation in the Republic of Croatia. Plans to work on the preservation of donkey breeds by including them primarily in tourism, to provide incentives for breeding, and to present and increase the supply of donkey milk. One of the main objectives was to address the topic of the specifics and differences of metabolic disorders with other equids. The conclusion we came to is that metabolic syndrome is one of the most common problems in donkeys and is quite similar to that in horses. Metabolic syndrome is a multisystem disorder that affects organs to varying degrees. This syndrome in donkeys is clinically manifested as non-regulation of insulin, recurrent laminitis and obesity. We have processed and pointed out the nutritional importance, quality and the main role in human nutrition with donkey milk. For now, this milk is mostly used as a substitute milk for newborns who accept it well. Comparing the components and their amount in human and donkey milk, we found that the two milk are very similar. We also concluded that there are potential dangers in the consumption of raw milk, so that monitoring should be carried out and more detailed research on the good and bad characteristics of donkey milk should be encouraged. Donkey's milk is known to have healing properties and is also used in cosmetics because of its effect.