S. pseudintermedius, S. schleiferi (including coagulase-negative strains) and S. aureus are the most common staphylococcal species that veterinarians encounter in small animal practice. They are commensals and opportunistic pathogens. Very often they are resistant to many antimicrobial classes. Contrary to outdated belief, coagulasenegative staphylococci can cause infections in dogs and cats. Thus, S. schleiferi would be considered pathogenic when it is isolated from an inflamed tissue or from pyogenic fluid. The treatment of staphylococcal infections most often occurs under the cover of canine pyoderma, because they are one of the most common causes of prescribing antimicrobial drugs in small practice. Emphasis is placed on the use of topical antiseptic/antimicrobial preparations in the case of superficial pyoderma and combining topical preparations with systemic antibiotics in the case of deep pyoderma. The choice of a systemic antibiotic should be based on the findings of the antibiogram, regional requirements for the use of antimicrobial classes and the circumstances linked to the patient (other diseases present, drug sensitivity, cooperation with the owner, etc.). The basis of infection control in veterinary hospitals is the isolation of infectious patients, the use of personal protective equipment, hand hygiene and cleaning and disinfection programs. Infected pets can be a source of infection for humans in which cases physical distance and adequate hygiene measures in the household are recommended during the treatment