According to the definition of the World Health Organization, COVID-19, is an infectious disease that primarily affects the respiratory system and is caused by the newly discovered coronavirus (SARS-CoV-2). COVID-19 is a physical disease and as such attracts public attention in terms of the number of infected, deceased as well as the physical health complications resulting from the disease. While it is important to focus on the physical consequences of the disease, monitoring other consequences is also important. Quality of life is used to describe the health of an individual or group, bodily functioning, symptoms of illness and injury, psychosocial adjustment, well-being as well as life satisfaction and happiness. The main goal of this paper is to determine the quality of life related to the health of physiotherapy students during the first wave of the COVID-19 virus epidemic. A cross-sectional survey was conducted. Data were collected by a survey questionnaire in the period from 10th of May to 17th of May 2020. The research was conducted on students of the " College of Applied Sciences "Lavoslav Ružička" in Vukovar. The data obtained indicate that during the first wave of the virus epidemic, there was a decline in health-related quality of life. The biggest difference is was observed in the domain of limitations due to emotional difficulties. Lower levels were observed in the domains of social functioning, physical pain, limitations due to physical difficulties but also lower levels of mental health. Also, all other domains, including physical functioning, general health perception, and vitality and energy show lower values.