Detection, prevention, and defense against Advanced Persistent Threats (APTs) are key elements in maintaining the security of organizational information systems and data. APT threats denote sophisticated cyber attacks that are often targeted, prolonged, and highly coordinated, capable of causing significant harm. Detection of APT threats requires advanced technologies such as Intrusion Detection Systems (IDS) and Security Information and Event Management (SIEM) systems, enabling continuous monitoring of network traffic and identification of suspicious activities. Prevention of APT attacks involves implementing multi-layered security architectures, utilizing advanced security tools such as firewalls, antivirus programs, and data encryption, as well as regularly updating software to patch security vulnerabilities. Defense against APT threats necessitates a proactive approach involving staff education on security practices, conducting regular security audits and testing, as well as collaboration with other organizations for sharing information on new threats and attacker tactics. A comprehensive approach that combines detection, prevention, and defense is crucial for successfully mitigating APT threats and safeguarding sensitive information and infrastructure.