The extremely frequent occurrence of CBRN threats and threats creates an increasing need for a functional multi-purpose NBC laboratory that would significantly contribute to national security. Compared to other laboratories, the NBC laboratory requires the fulfilment of certain standards and is subject to a special regime of work and safety at work, which makes the modelling of a NBC laboratory complex. The process does not necessarily include only theoretical analysis but is also based on practical or functional analysis. In addition to adequate and certified equipment and facilities, recognized instrumental identification methods, high-security facilities, adequate detection, and sampling facilities, protective equipment, and highly qualified personnel are required to complete the complete mosaic. In doing so, it is important to include and evaluate all design parameters of the NBC laboratory to ultimately create a realistic framework that implements simplicity, thoroughness, and efficiency.