Hazardous substances are the substances that can endanger human health, cause environmental pollution or material damage, which have dangerous properties for human health and the environment, which are defined as those laws, regulations and international agreements, which by virtue of their nature or properties and states, in relation to pose a danger to public security or order, or which have proven toxic, corrosive, irritant, flammable, explosive or radioactive effects, respectively, dangerous substances are considered to be the raw material from which to produce hazardous goods and wastes if they have properties of hazardous substances. How are dangerous substances indispensable raw materials in industry, energy source, and the refore an essential part of everyday life, transport of dangerous goods subject to the investigation by the geo-economic, ecological and safety point of view. Carriage of Dangerous Goods should be given special attention, carefully study the properties and characteristics of hazardous material, select the means of transport and to educate people who are in direct contact with hazardous substances.