prikaz prve stranice dokumenta Fluidity of the myelin sheath in the peripheral nerves of diabetic rats
  Download
PDF 297.55 KB
Scientific paper - Original scientific paper
Fluidity of the myelin sheath in the peripheral nerves of diabetic rats
Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease, 1537 (2001), 2; 110-116. https://doi.org/10.1016/S0925-4439(01)00063-1
Zuvić-Butorac, Marta; Križ, Jasna; Simonić, Ante; Schara, Milan

Institutional repository: Repository of the University of Rijeka, Faculty of Biotechnology and Drug Development

Cite this document

Zuvić Butorac, M., Križ, J., Simonić, A. & Schara, M. (2001). Fluidity of the myelin sheath in the peripheral nerves of diabetic rats. Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease, 1537. (2), 110-116. doi: 10.1016/S0925-4439(01)00063-1

Zuvić Butorac, Marta, et al. "Fluidity of the myelin sheath in the peripheral nerves of diabetic rats." Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease, vol. 1537, no. 2, 2001, pp. 110-116. https://doi.org/10.1016/S0925-4439(01)00063-1

Zuvić Butorac, Marta, Jasna Križ, Ante Simonić and Milan Schara. "Fluidity of the myelin sheath in the peripheral nerves of diabetic rats." Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease 1537, no. 2 (2001): 110-116. https://doi.org/10.1016/S0925-4439(01)00063-1

Zuvić Butorac, M., et al. (2001) 'Fluidity of the myelin sheath in the peripheral nerves of diabetic rats', Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease, 1537(2), pp. 110-116. doi: 10.1016/S0925-4439(01)00063-1

Zuvić Butorac M, Križ J, Simonić A, Schara M. Fluidity of the myelin sheath in the peripheral nerves of diabetic rats. Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease [Internet]. 2001 September [cited 2024 May 05];1537(2):110-116. doi: 10.1016/S0925-4439(01)00063-1

M. Zuvić Butorac, J. Križ, A. Simonić and M. Schara, "Fluidity of the myelin sheath in the peripheral nerves of diabetic rats", Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease, vol. 1537, no. 2, pp. 110-116, September 2001. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:193:905269. [Accessed: 05 May 2024]

Metadata
Title (english)Fluidity of the myelin sheath in the peripheral nerves of diabetic rats
AuthorMarta Zuvić-Butorac
AuthorJasna Križ
AuthorAnte Simonić
AuthorMilan Schara
Author's institutionUniversity of Rijeka
(Faculty of Biotechnology and Drug Development)
Scientific / art field,
discipline and subdiscipline		NATURAL SCIENCES
Physics
Biophysics and Medical Physics
Abstract (english)
In the present study we examined the structural integrity of the myelin sheath in the peripheral nerves from short-term streptozotocin (STZ)-treated diabetic rats, using ESR spectroscopy as a tool in determining the dynamic state and the structure of the myelin lipid phase. Experiments were performed on spin-labeled sciatic and sural nerves from STZ-treated Hannover–Wistar rats and age-matched controls. The spectrum analysis employed a numerical simulation model with the set of fitting parameters that in the same time relate the ESR line shape and structure and dynamics of the probed environment. The simulation considered three spectral components weighted and summed in the composite spectrum. The comparative analysis of results showed the fraction of the spectral component II to be significantly increased in the spectra of diabetic rats, indicating the significant increase in overall fluidity of the myelin structure. The origin of fluidity changes was further investigated using an experimental model for demyelination (local injection of ethidium bromide in vivo), proteolytic action of trypsin in vitro, and osmotic myelin swelling in vitro. Analysis and comparison of the results suggested a conclusion in terms of changed biophysical properties of the myelin lipid phase in peripheral nerves in the pathology of diabetes.
Keywords (english)
Languageenglish
Publication typeScientific paper - Original scientific paper
Publication statusPublished
Peer reviewPeer review - international
Publication versionPublished version
Journal titleBiochimica et Biophysica Acta (BBA) - Molecular Basis of Disease
Numberingvol. 1537, no. 2, pp. 110-116
p-ISSN0925-4439
DOIhttps://doi.org/10.1016/S0925-4439(01)00063-1
URN:NBNurn:nbn:hr:193:905269
Publication2001-09
Document URLhttps://www.sciencedirect.com/science/article/pii/S0925443901000631
Type of resourceText
Access conditionsOpen access
Terms of useLicence In copyright icon
Created on2018-09-30 18:27:07