prikaz prve stranice dokumenta Fluidity of the myelin sheath in the peripheral nerves of diabetic rats
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Fluidity of the myelin sheath in the peripheral nerves of diabetic rats
Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease, 1537 (2001), 2; 110-116. https://doi.org/10.1016/S0925-4439(01)00063-1
Zuvić-Butorac, Marta; Križ, Jasna; Simonić, Ante; Schara, Milan

Institucijski repozitorij: Repozitorij Fakulteta biotehnologije i razvoja lijekova

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Zuvić Butorac, M., Križ, J., Simonić, A. i Schara, M. (2001). Fluidity of the myelin sheath in the peripheral nerves of diabetic rats. Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease, 1537. (2), 110-116. doi: 10.1016/S0925-4439(01)00063-1

Zuvić Butorac, Marta, et al. "Fluidity of the myelin sheath in the peripheral nerves of diabetic rats." Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease, vol. 1537, br. 2, 2001, str. 110-116. https://doi.org/10.1016/S0925-4439(01)00063-1

Zuvić Butorac, Marta, Jasna Križ, Ante Simonić i Milan Schara. "Fluidity of the myelin sheath in the peripheral nerves of diabetic rats." Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease 1537, br. 2 (2001): 110-116. https://doi.org/10.1016/S0925-4439(01)00063-1

Zuvić Butorac, M., et al. (2001) 'Fluidity of the myelin sheath in the peripheral nerves of diabetic rats', Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease, 1537(2), str. 110-116. doi: 10.1016/S0925-4439(01)00063-1

Zuvić Butorac M, Križ J, Simonić A, Schara M. Fluidity of the myelin sheath in the peripheral nerves of diabetic rats. Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease [Internet]. 09.2001. [pristupljeno 15.05.2024.];1537(2):110-116. doi: 10.1016/S0925-4439(01)00063-1

M. Zuvić Butorac, J. Križ, A. Simonić i M. Schara, "Fluidity of the myelin sheath in the peripheral nerves of diabetic rats", Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease, vol. 1537, br. 2, str. 110-116, Rujan 2001. [Online]. Dostupno na: https://urn.nsk.hr/urn:nbn:hr:193:905269. [Citirano: 15.05.2024.]

Za citiranje koristite ovu mrežnu adresu: https://urn.nsk.hr/urn:nbn:hr:193:905269
Podaci o radu
Naslov (engleski)Fluidity of the myelin sheath in the peripheral nerves of diabetic rats
AutorMarta Zuvić-Butorac
AutorJasna Križ
AutorAnte Simonić
AutorMilan Schara
Autorova ustanovaSveučilište u Rijeci
(Fakultet biotehnologije i razvoja lijekova)
Znanstveno / umjetničko
područje, polje i grana		PRIRODNE ZNANOSTI
Fizika
Biofizika i medicinska fizika
Sažetak (engleski)
In the present study we examined the structural integrity of the myelin sheath in the peripheral nerves from short-term streptozotocin (STZ)-treated diabetic rats, using ESR spectroscopy as a tool in determining the dynamic state and the structure of the myelin lipid phase. Experiments were performed on spin-labeled sciatic and sural nerves from STZ-treated Hannover–Wistar rats and age-matched controls. The spectrum analysis employed a numerical simulation model with the set of fitting parameters that in the same time relate the ESR line shape and structure and dynamics of the probed environment. The simulation considered three spectral components weighted and summed in the composite spectrum. The comparative analysis of results showed the fraction of the spectral component II to be significantly increased in the spectra of diabetic rats, indicating the significant increase in overall fluidity of the myelin structure. The origin of fluidity changes was further investigated using an experimental model for demyelination (local injection of ethidium bromide in vivo), proteolytic action of trypsin in vitro, and osmotic myelin swelling in vitro. Analysis and comparison of the results suggested a conclusion in terms of changed biophysical properties of the myelin lipid phase in peripheral nerves in the pathology of diabetes.
Ključne riječi (engleski)
Jezikengleski
Vrsta publikacijeZnanstveni rad - Izvorni znanstveni rad
Status objaveObjavljen
Vrsta recenzijeRecenziran - međunarodna recenzija
Verzija publikacijeObjavljena verzija rada (izdavačev PDF)
Naslov časopisaBiochimica et Biophysica Acta (BBA) - Molecular Basis of Disease
Brojčani podacivol. 1537, br. 2, str. 110-116
p-ISSN0925-4439
DOIhttps://doi.org/10.1016/S0925-4439(01)00063-1
URN:NBNurn:nbn:hr:193:905269
Datum objave publikacije2001-09
URL dokumentahttps://www.sciencedirect.com/science/article/pii/S0925443901000631
Vrsta resursaTekst
Prava pristupaOtvoreni pristup
Uvjeti korištenjaIkona licence Zaštićeno autorskim pravom.
Datum i vrijeme pohrane2018-09-30 18:27:07