Menkes disease is a rare genetic disorder that affects copper metabolism. It’s linked with male children with an average of 1: 100 000 new-borns affected by it. The disease causes poor distribution of copper in the body. Patients are hypotonic and have developmental difficulties with some cases displaying major cognitive disabilities. Life expectancy is around 3 years, but there are some milder forms of the disease. Keeping in mind that persons/children with Menkes disease often cannot communicate in a usual way, they are associated with alternative and augmentative communication (AAC) as means of encouraging communication. The term AAC refers to any and all means of communication which enhance or completely take over the already existing means of communication. This Master’s Thesis will follow therapy done with a boy who has been diagnosed with an atypical/mild form of Menkens disease (KA=5) as well as accompanied learning and developmental difficulties. He was included in one-year speech language pathological guidance (once a week), focused on encouraging communication and lingual understanding with introduction of AAC. The goal of this research was to monitor and describe communication and speech and language development in a child with Menkes syndrome along the course of applying different methods of AAC. The boy’s means of communication, functions and progress were monitored based on the Pragmatic development profile. During the encouragement the methods were adapted according to the boy's progress (such as, fulfilling the conditions to introduce the switch). In the last two months of the therapy, progress in the "requesting repetition" is noticeable. Also, the boy showed progress responding to communication encouragement, playing and showing independence. Considering the lack of literature concerning communication and speech and language development of persons/children with Menkes disease, this thesis contributes detailed description of communication profile of a child with an atypical/mild form of Menkes disease, but also the possibility of introduction of AAC in this case. When introducing AAC it is essential to cooperate with parents who have the opportunity to use AAC in their everyday life.