prikaz prve stranice dokumenta Algoritmi za utvrđivanje fleksibilnosti proteina na temelju konformacije i fizikalnih svojstava proteina
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doctoral thesis
Algoritmi za utvrđivanje fleksibilnosti proteina na temelju konformacije i fizikalnih svojstava proteina
Zagreb: University of Zagreb, Faculty of Electrical Engineering and Computing, 2008. urn:nbn:hr:168:483110
Šikić, Krešimir
University of Zagreb
Faculty of Electrical Engineering and Computing
Department of Electronic Systems and Information Processing
Ruđer Bošković Institute

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Šikić, K. (2008). Algoritmi za utvrđivanje fleksibilnosti proteina na temelju konformacije i fizikalnih svojstava proteina (Doctoral thesis). Zagreb: University of Zagreb, Faculty of Electrical Engineering and Computing; Zagreb: Ruđer Bošković Institute. Retrieved from https://urn.nsk.hr/urn:nbn:hr:168:483110

Šikić, Krešimir. "Algoritmi za utvrđivanje fleksibilnosti proteina na temelju konformacije i fizikalnih svojstava proteina." Doctoral thesis, University of Zagreb, Faculty of Electrical Engineering and Computing; Ruđer Bošković Institute, 2008. https://urn.nsk.hr/urn:nbn:hr:168:483110

Šikić, Krešimir. "Algoritmi za utvrđivanje fleksibilnosti proteina na temelju konformacije i fizikalnih svojstava proteina." Doctoral thesis, University of Zagreb, Faculty of Electrical Engineering and Computing; Ruđer Bošković Institute, 2008. https://urn.nsk.hr/urn:nbn:hr:168:483110

Šikić, K. (2008). 'Algoritmi za utvrđivanje fleksibilnosti proteina na temelju konformacije i fizikalnih svojstava proteina', Doctoral thesis, University of Zagreb, Faculty of Electrical Engineering and Computing; Ruđer Bošković Institute, accessed 14 March 2025, https://urn.nsk.hr/urn:nbn:hr:168:483110

Šikić K. Algoritmi za utvrđivanje fleksibilnosti proteina na temelju konformacije i fizikalnih svojstava proteina [Doctoral thesis]. Zagreb: University of Zagreb, Faculty of Electrical Engineering and Computing; Zagreb: Ruđer Bošković Institute; 2008 [cited 2025 March 14] Available at: https://urn.nsk.hr/urn:nbn:hr:168:483110

K. Šikić, "Algoritmi za utvrđivanje fleksibilnosti proteina na temelju konformacije i fizikalnih svojstava proteina", Doctoral thesis, University of Zagreb, Faculty of Electrical Engineering and Computing, Zagreb; Ruđer Bošković Institute, Zagreb, 2008. Available at: https://urn.nsk.hr/urn:nbn:hr:168:483110

Metadata
TitleAlgoritmi za utvrđivanje fleksibilnosti proteina na temelju konformacije i fizikalnih svojstava proteina
Title (english)Algorithms for determination of protein flexibility based on conformations and physical properties of protein
AuthorKrešimir Šikić
MentorBranko Jeren (mentor)
MentorSanja Tomić (komentor)
Committee memberSven Lončarić (član povjerenstva)
Committee memberBranko Jeren (član povjerenstva)
Committee memberSanja Tomić (član povjerenstva)
Committee memberMladen Kos (član povjerenstva)
Committee memberDavor Petrinović (član povjerenstva)
GranterUniversity of Zagreb
Faculty of Electrical Engineering and Computing
(Department of Electronic Systems and Information Processing)
Zagreb
GranterRuđer Bošković Institute
Zagreb
Defense date and country2008-09-29, Croatia
Scientific / art field,
discipline and subdiscipline		TECHNICAL SCIENCES
Electrical Engineering
Electronics
Scientific / art field,
discipline and subdiscipline		TECHNICAL SCIENCES
Computing
Data Processing
Scientific / art field,
discipline and subdiscipline		INTERDISCIPLINARY AREAS OF KNOWLEDGE
Biotechnology in Biomedicine (natural science, biomedicine and healthcare, bioethics area
Universal decimal classification
(UDC)		621.3 - Electrical engineering
60 - Biotechnology. Genetic engineering. Products of cloning
Abstract
Tema ovog rada je proučavanje fleksibilnosti proteina. U cilju proučavanja fleksibilnosti proteina u radu su predložene dvije nove metode za utvrđivanje fleksibilnosti. Metode su apriori i aposteriori. Prva metoda identificira fleksibilne i rigidne domene u proteinu na temelju karakteristika jednog prostornog oblika korištenjem kompleksnih modela i aproksimacija. Druga metoda se temelji na usporedbi dvaju prostornih oblika istog proteina. Prva metoda je točnija iz razloga što uzima u... More razmatranje dva prostorna oblika, ali nije uvijek upotrebljiva. Druga metoda se može uvijek primijeniti jer zahtijeva samo jedan prostorni oblik. Usporedbom rezultata dobivenih korištenjem ovih metoda dokazano je da je apriori dovoljno točna kako bi se mogla koristiti u budućim istraživanjima. Temeljem apostreriori metode napravljen je testni skup koji je moguće koristiti za testiranje novih metoda za određivanje fleksibilnosti. Kako obradba informacija u ovom radu ovisi o PDB zapisima napravljena je i sveobuhvatna usporedba PDB zapisa dobivenih različitim tehnikama. Na ovaj način su utvrđene razlike u zapisima koje mogu utjecati na istraživanja. Less
Abstract (english)
This thesis is focused on studying protein flexibility. For that purpose two new methods for protein flexibility identification based on information processing have been proposed. Methods are named apriori and aposteriori. First method identifies flexible and rigid domains in protein on a basis of single conformation properties using complex models and approximations. Second method relies on comparison of two conformations of the same protein. However, I consider first method to be... More more accurate one but due to its limitations (two conformations required) it is not always applicable, while second method requiring only one conformation can always be applied. By comparing results obtained with these methods I have proofed that the accuracy of the apriori is high enough to be use in future studies. Also using proposed aposteriori a limited size benchmark for the purpose of developing future methods has been created. As information processing in this thesis relies on PDB entries a large scale comparison between different types of entries has been done in order to determine differences and possible pitfalls in the research. Less
Keywords
Keywords (english)
Languagecroatian
URN:NBNurn:nbn:hr:168:483110
Study programmeTitle: Electrical Engineering and Computing
Study programme type: university
Study level: postgraduate
Academic / professional title: Doktor znanosti elektrotehnike i računarstva (Doktor znanosti elektrotehnike i računarstva)
Type of resourceText
File originBorn digital
Access conditionsClosed access
Terms of useLicence In copyright icon
Created on2020-05-26 06:24:20
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