prikaz prve stranice dokumenta Sinteza i karakterizacija novih izoksazolnih derivata uracila s potencijalnom antitumorskom aktivnošću
No public access
undergraduate thesis
Sinteza i karakterizacija novih izoksazolnih derivata uracila s potencijalnom antitumorskom aktivnošću
Zagreb: University of Zagreb, Faculty of Chemical Engineering and Technology, 2022. urn:nbn:hr:149:723525
Damjanović, Lorena
University of Zagreb
Faculty of Chemical Engineering and Technology

Institutional repository: Repository of Faculty of Chemical Engineering and Technology University of Zagreb

Cite this document

Damjanović, L. (2022). Sinteza i karakterizacija novih izoksazolnih derivata uracila s potencijalnom antitumorskom aktivnošću (Undergraduate thesis). Zagreb: University of Zagreb, Faculty of Chemical Engineering and Technology. Retrieved from https://urn.nsk.hr/urn:nbn:hr:149:723525

Damjanović, Lorena. "Sinteza i karakterizacija novih izoksazolnih derivata uracila s potencijalnom antitumorskom aktivnošću." Undergraduate thesis, University of Zagreb, Faculty of Chemical Engineering and Technology, 2022. https://urn.nsk.hr/urn:nbn:hr:149:723525

Damjanović, Lorena. "Sinteza i karakterizacija novih izoksazolnih derivata uracila s potencijalnom antitumorskom aktivnošću." Undergraduate thesis, University of Zagreb, Faculty of Chemical Engineering and Technology, 2022. https://urn.nsk.hr/urn:nbn:hr:149:723525

Damjanović, L. (2022). 'Sinteza i karakterizacija novih izoksazolnih derivata uracila s potencijalnom antitumorskom aktivnošću', Undergraduate thesis, University of Zagreb, Faculty of Chemical Engineering and Technology, accessed 02 January 2025, https://urn.nsk.hr/urn:nbn:hr:149:723525

Damjanović L. Sinteza i karakterizacija novih izoksazolnih derivata uracila s potencijalnom antitumorskom aktivnošću [Undergraduate thesis]. Zagreb: University of Zagreb, Faculty of Chemical Engineering and Technology; 2022 [cited 2025 January 02] Available at: https://urn.nsk.hr/urn:nbn:hr:149:723525

L. Damjanović, "Sinteza i karakterizacija novih izoksazolnih derivata uracila s potencijalnom antitumorskom aktivnošću", Undergraduate thesis, University of Zagreb, Faculty of Chemical Engineering and Technology, Zagreb, 2022. Available at: https://urn.nsk.hr/urn:nbn:hr:149:723525

Metadata
TitleSinteza i karakterizacija novih izoksazolnih derivata uracila s potencijalnom antitumorskom aktivnošću
Title (english)Synthesis and characterization of novel isoxazole uracil derivatives as potential antitumor agents
AuthorLorena Damjanović
MentorSilvana Raić-Malić (mentor)
Committee memberSilvana Raić-Malić (predsjednik povjerenstva)
Committee memberTatjana Gazivoda Kraljević (član povjerenstva)
Committee memberDanijela Ašperger (član povjerenstva)
GranterUniversity of Zagreb
Faculty of Chemical Engineering and Technology
Zagreb
Defense date and country2022-09-16, Croatia
Scientific / art field,
discipline and subdiscipline		NATURAL SCIENCES
Chemistry
Abstract
U ovom radu opisana je sinteza novih uracilnih i piridinskih derivata povezanih izoksazolnom poveznicom 6a–f. N-propargilirani derivati uracila 5a–f priređeni su reakcijom alkiliranja. Odgovarajući oksim (3) potreban za sintezu izoksazolnih derivata priređen je reakcijom kloriranja piridin-2-aldoksima. Ciljani derivati 6a–f priređeni su potom bazno kataliziranom 1,3-dipolarnom cikloadicijom iz propargiliranih derivata 5a–f i kloriranog oksima 3. Dobiveni izoksazolni derivati 6a–f korišteni su kao ligandi za sintezu Re(I) kompleksa 7a–f. Nadalje, dobiveni 5-joduracilni derivat supstituiran je u položaju C-5 uporabom paladij-bakar katalizirane Sonogashire reakcije unakrsnog spajanja. Strukture novosintetiziranih spojeva potvrđene su spektroskopijom 1H i 13C NMR. Naknadno će se provesti antitumorska ispitivanja novosintetiziranih spojeva.
Abstract (english)
In this work the synthesis of novel uracil and pyridine derivatives linked via isoxazole spacer (6a–f) is described. N-propargylated uracil derivatives 5a–f were prepared by alkylation reaction. The corresponding oxime 3 for the synthesis of isoxazole derivatives was synthesized by the chlorination reaction of pyridine-2-aldoxime. The targer isoxazole derivatives 6a–f were prepared by base-catalyzed 1,3-dipolar cycloaddition of propargylated uracil derivatives 5a–f and chlorinated oxime 3. Synthesized isoxazole derivatives 6a–f were subsequently used as ligands for the synthesis of Re(I) complexes 7a–f. They were also functionalized at C-5 position of uracil moiety using Sonogashira cross-coupling reaction. The structures of all compounds were determined by 1H NMR and 13C NMR spectroscopy. Anticancer evaluations of these compounds will be performed.
Keywords
Keywords (english)
Languagecroatian
URN:NBNurn:nbn:hr:149:723525
ProjectNumber: IP-2018-01-4682
Title: Novi spojevi temeljeni na bioizosterima purina za ispitivanje njihovih antitumorskih i antipatogenih djelovanja
Acronym: PurBioCaPa
Leader: Silvana Raić-Malić
Jurisdiction: Croatia
Funder: HRZZ
Funding stream: IP
Study programmeTitle: Applied Chemistry - Undergraduate study; specializations in: Environmental chemistry and green technologies, Advanced materials and technologies, Applied organic chemistry
Course: Applied organic chemistry
Study programme type: university
Study level: undergraduate
Academic / professional title: sveučilišni/a prvostupnik/prvostupnica (baccalaureus/baccalaurea) primijenjene kemije (sveučilišni/a prvostupnik/prvostupnica (baccalaureus/baccalaurea) primijenjene kemije)
Type of resourceText
File originBorn digital
Access conditionsClosed access
Terms of useLicence In copyright icon
Created on2023-02-22 12:40:47