prikaz prve stranice dokumenta Sinteza novih piridin-oksimskih i ferocen-oksimskih derivata kao potencijalnih antitumorskih agensa
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undergraduate thesis
Sinteza novih piridin-oksimskih i ferocen-oksimskih derivata kao potencijalnih antitumorskih agensa
Zagreb: University of Zagreb, Faculty of Chemical Engineering and Technology, 2022. urn:nbn:hr:149:968800
Vitković, Klara
University of Zagreb
Faculty of Chemical Engineering and Technology

Institutional repository: Repository of Faculty of Chemical Engineering and Technology University of Zagreb

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Vitković, K. (2022). Sinteza novih piridin-oksimskih i ferocen-oksimskih derivata kao potencijalnih antitumorskih agensa (Undergraduate thesis). Zagreb: University of Zagreb, Faculty of Chemical Engineering and Technology. Retrieved from https://urn.nsk.hr/urn:nbn:hr:149:968800

Vitković, Klara. "Sinteza novih piridin-oksimskih i ferocen-oksimskih derivata kao potencijalnih antitumorskih agensa." Undergraduate thesis, University of Zagreb, Faculty of Chemical Engineering and Technology, 2022. https://urn.nsk.hr/urn:nbn:hr:149:968800

Vitković, Klara. "Sinteza novih piridin-oksimskih i ferocen-oksimskih derivata kao potencijalnih antitumorskih agensa." Undergraduate thesis, University of Zagreb, Faculty of Chemical Engineering and Technology, 2022. https://urn.nsk.hr/urn:nbn:hr:149:968800

Vitković, K. (2022). 'Sinteza novih piridin-oksimskih i ferocen-oksimskih derivata kao potencijalnih antitumorskih agensa', Undergraduate thesis, University of Zagreb, Faculty of Chemical Engineering and Technology, accessed 29 November 2024, https://urn.nsk.hr/urn:nbn:hr:149:968800

Vitković K. Sinteza novih piridin-oksimskih i ferocen-oksimskih derivata kao potencijalnih antitumorskih agensa [Undergraduate thesis]. Zagreb: University of Zagreb, Faculty of Chemical Engineering and Technology; 2022 [cited 2024 November 29] Available at: https://urn.nsk.hr/urn:nbn:hr:149:968800

K. Vitković, "Sinteza novih piridin-oksimskih i ferocen-oksimskih derivata kao potencijalnih antitumorskih agensa", Undergraduate thesis, University of Zagreb, Faculty of Chemical Engineering and Technology, Zagreb, 2022. Available at: https://urn.nsk.hr/urn:nbn:hr:149:968800

Metadata
TitleSinteza novih piridin-oksimskih i ferocen-oksimskih derivata kao potencijalnih antitumorskih agensa
Title (english)Synthesis of novel pyridin-oxime and ferrocene-oxime derivatives as potential antitumor agents
AuthorKlara Vitković
MentorSilvana Raić-Malić (mentor)
Committee memberSilvana Raić-Malić (predsjednik povjerenstva)
Committee memberTatjana Gazivoda Kraljević (član povjerenstva)
Committee memberDanijela Ašperger (član povjerenstva)
GranterUniversity of Zagreb
Faculty of Chemical Engineering and Technology
Zagreb
Defense date and country2022-09-26, Croatia
Scientific / art field,
discipline and subdiscipline		NATURAL SCIENCES
Chemistry
Abstract
Cilj ovog rada bila je sinteza novih piridin-oksimskih (49–52, 54–62) i ferocenoksimskih derivata (46–48, 53) kao potencijalnih antitumorskih agensa. U tu svrhu provedena je sinteza piridin-2-aldoksima (49) te naknadno njegovo O-alkiliranje. Provedena je zatim sinteza mono- i bis-ferocenskih azida (45a, 45b) iz ferocen alkohola. Reakcijom 1,3-dipolarne cikloadicije terminalnog alkina i ferocenskog azida dobiveni su mono- i bis-supstituirani ferocen-oksimski-1,2,3-triazolni derivati (46, 48, 53). U ovom radu također je provedeno uvođenje benzoilne zaštitne skupine na uracilu, 5-kloruracilu i timinu. Potom su provedene reakcije nukleofilne supstitucije uracila, 5-kloruracila i timina, sa i bez zaštitne skupine, s brometil-piridin-2-aldoksimom (52). U obje reakcije dobiveni su mono- i bis-derivati (57–62). Strukture novopripravljenih spojeva potvrđena je 1H i 13C NMR spektroskopijom.
Abstract (english)
The goal of this work was the synthesis of new pyridine-oxime (49–52, 54–62) and ferrocene-oxime derivatives (46–48, 53) as potential antitumor agents. For this purpose, the synthesis of pyridine-2-aldoxime (49) and subsequent its O-alkylation were carried out. The synthesis of mono- and bis-ferrocene azides (45a, 45b) from ferrocene alcohol was also carried out. By the 1,3-dipolar cycloaddition reaction of terminal alkyne and ferrocene azide, monoand bis-substituted ferrocene-oxime derivatives (46, 48, 53) were obtained. In this work, the introduction of a benzoyl protecting group on uracil, 5-chloro-uracil and thymine moiety was also carried out. Nucleophilic substitution reactions of uracil, 5-chlorouracil and thymine, with and without protecting group, were then carried out with bromomethyl-pyridine-2-aldoxime (52). In both reactions, mono- and bis-derivatives (57–62) were obtained. The structures of newly synthesised compound were confirmed by 1H and 13C NMR spectroscopy.
Keywords
Keywords (english)
Languagecroatian
URN:NBNurn:nbn:hr:149:968800
ProjectNumber: IP-2018-01-4682
Title: Novi spojevi temeljeni na bioizosterima purina za ispitivanje njihovih antitumorskih i antipatogenih djelovanja
Acronym: PurBioCaPa
Leader: Silvana Raić-Malić
Jurisdiction: Croatia
Funder: HRZZ
Funding stream: IP
Study programmeTitle: Applied Chemistry - Undergraduate study; specializations in: Environmental chemistry and green technologies, Advanced materials and technologies, Applied organic chemistry
Course: Applied organic chemistry
Study programme type: university
Study level: undergraduate
Academic / professional title: sveučilišni/a prvostupnik/prvostupnica (baccalaureus/baccalaurea) primijenjene kemije (sveučilišni/a prvostupnik/prvostupnica (baccalaureus/baccalaurea) primijenjene kemije)
Type of resourceText
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Created on2023-03-14 12:16:54