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undergraduate thesis
Mikrorazinski studij fenomena granuliranja primjenom parametara međupovršine prašak-vezivo
Zagreb: University of Zagreb, Faculty of Chemical Engineering and Technology, 2016. urn:nbn:hr:149:002056
Košić, Ivona
University of Zagreb
Faculty of Chemical Engineering and Technology

Institutional repository: Repository of Faculty of Chemical Engineering and Technology University of Zagreb

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Košić, I. (2016). Mikrorazinski studij fenomena granuliranja primjenom parametara međupovršine prašak-vezivo (Undergraduate thesis). Zagreb: University of Zagreb, Faculty of Chemical Engineering and Technology. Retrieved from https://urn.nsk.hr/urn:nbn:hr:149:002056

Košić, Ivona. "Mikrorazinski studij fenomena granuliranja primjenom parametara međupovršine prašak-vezivo." Undergraduate thesis, University of Zagreb, Faculty of Chemical Engineering and Technology, 2016. https://urn.nsk.hr/urn:nbn:hr:149:002056

Košić, Ivona. "Mikrorazinski studij fenomena granuliranja primjenom parametara međupovršine prašak-vezivo." Undergraduate thesis, University of Zagreb, Faculty of Chemical Engineering and Technology, 2016. https://urn.nsk.hr/urn:nbn:hr:149:002056

Košić, I. (2016). 'Mikrorazinski studij fenomena granuliranja primjenom parametara međupovršine prašak-vezivo', Undergraduate thesis, University of Zagreb, Faculty of Chemical Engineering and Technology, accessed 20 December 2024, https://urn.nsk.hr/urn:nbn:hr:149:002056

Košić I. Mikrorazinski studij fenomena granuliranja primjenom parametara međupovršine prašak-vezivo [Undergraduate thesis]. Zagreb: University of Zagreb, Faculty of Chemical Engineering and Technology; 2016 [cited 2024 December 20] Available at: https://urn.nsk.hr/urn:nbn:hr:149:002056

I. Košić, "Mikrorazinski studij fenomena granuliranja primjenom parametara međupovršine prašak-vezivo", Undergraduate thesis, University of Zagreb, Faculty of Chemical Engineering and Technology, Zagreb, 2016. Available at: https://urn.nsk.hr/urn:nbn:hr:149:002056

Metadata
TitleMikrorazinski studij fenomena granuliranja primjenom parametara međupovršine prašak-vezivo
Title (english)The micro scale study of granulation phenomenon using parameters of powder-binder interface
AuthorIvona Košić
MentorKrunoslav Žižek (mentor)
Committee memberKrunoslav Žižek (predsjednik povjerenstva)
Committee memberGordana Matijašić (član povjerenstva)
Committee memberMirela Leskovac (član povjerenstva)
GranterUniversity of Zagreb
Faculty of Chemical Engineering and Technology
Zagreb
Defense date and country2016-07-13, Croatia
Scientific / art field,
discipline and subdiscipline		TECHNICAL SCIENCES
Chemical Engineering
Mechanical, Thermal and Separation Processes
Abstract
U ovome je radu sagledano granuliranje dviju pomoćnih tvari farmaceutske industrije u fluidiziranom sloju s taljenjem sa stajališta mikrorazine procesa. Testovi šaržnog granuliranja provedeni su prethodnim istraživanjem u procesnoj geometriji fluidiziranog sloja u laboratorijskom mjerilu. U fizičkoj pretvorbi tvari korišteno je vezivo, praškasti polietilen glikol koji taljenjem osigurava nužna kapljevita premoštenja. Mikrorazinski studij fenomena granuliranja usmjeren je k pronalaženju parametara međupovršine prašak-vezivo za sustave mikrokristalna celuloza/polietilen glikol i laktoza monohidrat/polietilen glikol. U karakterizaciji dviju međupovršina od značaja korištena je eksperimentalna tehnika mjerenja kontaktnog kuta goniometrom. Određeni su kontaktni kutovi triju testnih kapljevina poznatih energija površina na supstratima mikrokristalne celuloze, laktoze monohidrata i polietilen glikola. U kvantitativnom predviđanju interakcija korišteni su dvoparametarski modeli. Primjenom Owens-Wendtova i Wuova modela procijenjene su slobodne energije površina pojedinih faza, energije međupovršina od značaja te pripadajuće vrijednosti termodinamičkog rada adhezije i koeficijenta kvašenja. Parametri adhezije ukazuju na slabe interakcije između mikrokristalne celuloze i polietilen glikola te mogućnost odvajanja faza i posljedično na nemogućnost granuliranja ovog sustava. Dodatno, parametri međupovršine ukazuju na mogućnost uspostave značajnih interakcija između laktoze monohidrata i polietilen glikola.
Abstract (english)
In this thesis, fluidized bed melt granulation of two pharmaceutical excipients is scrutinized from a micro scale level of scrutiny. Batch granulation tests were performed by previous research in process geometry of fluidized bed in a lab-scale. Binder, polyethylene glycol powder that provides necessary liquid bridges by melting, is used in physical conversion of a substance. The micro scale study of granulation phenomenon is focused towards detection of parameters of powder-binder interface for systems microcrystalline cellulose/polyethylene glycol and lactose monohydrate/polyethylene glycol. Experimental technique for measurement of contact angle using goniometer is used for characterization of two interfaces of interest. Contact angles of three test liquids with well known surface energies were determined on substrates of microcrystalline cellulose, lactose monohydrate and polyethylene glycol. Two parametric models were used for quantitative prediction of interactions. Surface free energies for each phase, interfacial energies of interest and corresponding values of thermodynamic work of adhesion and spreading coefficient were estimated using Owens-Wendt and Wu model. Adhesion parameters indicate weak interactions between microcrystalline cellulose and polyethylene glycol with possibility of phase dewetting and consequently on the inability for granulation of this system. Additionally, interface parameters indicate the possibility for establishment of considerable interactions between lactose monohydrate and polyethylene glycol.
Keywords
Keywords (english)
Languagecroatian
URN:NBNurn:nbn:hr:149:002056
Study programmeTitle: Applied Chemistry - Undergraduate study; specializations in: Environmental chemistry and green technologies, Advanced materials and technologies, Applied organic chemistry
Course: Advanced materials and technologies
Study programme type: university
Study level: undergraduate
Academic / professional title: sveučilišni/a prvostupnik/prvostupnica (baccalaureus/baccalaurea) primijenjene kemije (sveučilišni/a prvostupnik/prvostupnica (baccalaureus/baccalaurea) primijenjene kemije)
Type of resourceText
File originBorn digital
Access conditionsOpen access
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Created on2017-12-11 09:52:29